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However, the role of BZP in cardiac diseases, especially in pressure overload\u2010induced cardiac hypertrophy and heart failure, remains to be investigated. In the present study, angiotensin II stimulation and transverse aortic constriction were employed to induce cardiomyocyte hypertrophy in vitro and in vivo, respectively, prior to the assessment of myocardial cell autophagy. We observed that BZP administration ameliorated cardiomyocyte hypertrophy and excessive autophagic activity. Further results indicated that AMP\u2010activated protein kinase (AMPK)\u2010mediated activation of the mammalian target of rapamycin (mTOR) pathway likely played a role in regulation of autophagy by BZP after Ang II stimulation. The activation of AMPK with metformin reversed the BZP\u2010induced suppression of autophagy. Finally, for the first time, we demonstrated that BZP could protect the heart from pressure overload\u2010induced hypertrophy and dysfunction, and this effect is associated with its inhibition of maladaptive cardiomyocyte autophagy through the AMPK\u2010mTOR signalling pathway. These findings indicated that BZP may serve as a promising compound for treatment of pressure overload\u2010induced cardiac remodelling and heart failure.<\/jats:p>","DOI":"10.1111\/jcmm.14468","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T06:56:08Z","timestamp":1561100168000},"page":"6048-6059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Sodium (\u00b1)\u20105\u2010bromo\u20102\u2010(\u03b1\u2010hydroxypentyl) benzoate ameliorates pressure overload\u2010induced cardiac hypertrophy and dysfunction through inhibiting autophagy"],"prefix":"10.1111","volume":"23","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Henan Province Key Laboratory of Cardiac Injury and Repair The First Affiliated Hospital of Zhengzhou University Zhengzhou P. R. 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