{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:01:40Z","timestamp":1777561300527,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T00:00:00Z","timestamp":1561075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470516"],"award-info":[{"award-number":["81470516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increase of myocardial oxidative stress is closely related to the occurrence and development of cardiac hypertrophy. Cordycepin, also known as 3'\u2010deoxyadenosine, is a natural bioactive substance extracted from <jats:italic>Cordyceps militaris<\/jats:italic> (which is widely cultivated for commercial use in functional foods and medicine). Since cordycepin suppresses oxidative stress both in vitro and in vivo, we hypothesized that cordycepin would inhibit cardiac hypertrophy by blocking oxidative stress\u2010dependent related signalling. In our study, a mouse model of cardiac hypertrophy was induced by aortic banding (AB) surgery. Mice were intraperitoneally injected with cordycepin (20\u00a0mg\/kg\/d) or the same volume of vehicle 3\u00a0days after\u2010surgery for 4\u00a0weeks. Our data demonstrated that cordycepin prevented cardiac hypertrophy induced by AB, as assessed by haemodynamic parameters analysis and echocardiographic, histological and molecular analyses. Oxidative stress was estimated by detecting superoxide generation, superoxide dismutase (SOD) activity and malondialdehyde levels, and by detecting the protein levels of gp91<jats:sup>phox<\/jats:sup> and SOD. Mechanistically, we found that cordycepin activated activated protein kinase \u03b1 (AMPK\u03b1) signalling and attenuated oxidative stress both in vivo in cordycepin\u2010treated mice and in vitro in cordycepin treated cardiomyocytes. Taken together, the results suggest that cordycepin protects against post\u2010AB cardiac hypertrophy through activation of the AMPK\u03b1 pathway, which subsequently attenuates oxidative stress.<\/jats:p>","DOI":"10.1111\/jcmm.14485","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T10:05:15Z","timestamp":1561111515000},"page":"5715-5727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Cordycepin ameliorates cardiac hypertrophy via activating the AMPK\u03b1 pathway"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-7419","authenticated-orcid":false,"given":"Hui\u2010Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan PR China"},{"name":"Hubei Key Laboratory of Metabolic and Chronic Diseases Wuhan RP China"},{"name":"Department of Cardiology, The First College 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