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It is enhanced in many osteoclast\u2010related diseases including osteoporosis and periprosthetic osteolysis. The shortage of effective treatments for these pathological processes emphasizes the importance of screening and identifying potential regimens that could attenuate the formation and function of osteoclasts. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone containing anti\u2010inflammatory properties. Here, we showed that DHE suppressed receptor activator of nuclear factor\u2010\u03baB ligand (RANKL)\u2010induced osteoclast formation and osteoclast marker gene expression. It also inhibited F\u2010actin ring formation and bone resorption in a dose\u2010dependent manner in vitro. Moreover, DHE inhibited the RANKL\u2010induced phosphorylation of NF\u2010\u03baB, mitigated bone erosion in vivo in lipopolysaccharide\u2010induced inflammatory bone loss model and particle\u2010induced calvarial osteolysis model. Together, these results suggest that DHE reduces osteoclast\u2010related bone loss via the modulation of NF\u2010\u03baB activation during osteoclastogenesis indicating that it might be a useful treatment for osteoclast\u2010related skeletal disorders.<\/jats:p>","DOI":"10.1111\/jcmm.14492","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T11:05:27Z","timestamp":1561115127000},"page":"5762-5770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dehydrocostus lactone attenuates osteoclastogenesis and osteoclast\u2010induced bone loss by modulating NF\u2010\u03baB signalling pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Bin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Orthopedic Research Institute of Zhejiang University 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