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Since its side effects include skin dryness, whereas its deficiency can be accompanied by dyssebacia, characterized by sebaceous gland enlargement, we asked if HCA<jats:sub>2<\/jats:sub> is expressed on human sebocytes, and if NA influences sebocyte functions. By using human immortalized SZ95 sebocytes, we found that non\u2010cytotoxic (\u2264100\u00a0\u03bcmol\/L; MTT\u2010assay) concentrations of NA had no effect on the homeostatic sebaceous lipogenesis (SLG; Nile Red), but normalized excessive, acne\u2010mimicking SLG induced by several lipogenic agents (arachidonic acid, anandamide, linoleic acid\u00a0+\u00a0testosterone; Nile Red; 48\u2010hr treatments). Moreover, it exerted significant anti\u2010proliferative actions (CyQUANT\u2010assay), and increased [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>IC<\/jats:sub> (Fluo\u20104 AM\u2010based Ca<jats:sup>2+<\/jats:sup>\u2010measurement). Although NA did not prevent the lipopolysaccharide\u2010induced pro\u2010inflammatory response (up\u2010regulation [Q\u2010PCR] and release [ELISA] of several pro\u2010inflammatory cytokines) of the sebocytes, collectively, these data support the concept that NA may be effective in suppressing sebum production in vivo. While exploring the mechanism of the sebostatic actions, we found that sebocytes express HCA<jats:sub>2<\/jats:sub> (Q\u2010PCR, immunofluorescent labelling), siRNA\u2010mediated silencing of which prevented the NA\u2010induced Ca<jats:sup>2+<\/jats:sup>\u2010signal and the lipostatic action. Collectively, our data introduce NA, and HCA<jats:sub>2<\/jats:sub> activators in general, as novel, potent and most likely safe sebostatic agents, with possible anti\u2010acne potential.<\/jats:p>","DOI":"10.1111\/jcmm.14505","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:20:11Z","timestamp":1562311211000},"page":"6203-6214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA<sub>2<\/sub>)"],"prefix":"10.1111","volume":"23","author":[{"given":"Arnold","family":"Markovics","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-8082","authenticated-orcid":false,"given":"Kinga Fanni","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin Eszter","family":"S\u00f3s","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Debrecen Debrecen Hungary"},{"name":"Laboratory of Cerebral Cortex Research, Institute of Experimental Medicine Hungarian Academy of Sciences Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Magi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienn","family":"Gy\u00f6ngy\u00f6si","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-0359","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Beny\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Clinical Experimental Research Semmelweis University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center Brandenburg Medical School Theodor Fontane Dessau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-6221","authenticated-orcid":false,"given":"Tam\u00e1s","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"DE\u2010MTA \u201cLend\u00fclet\u201d Cellular Physiology Research Group, Department of Immunology, Faculty of Medicine University of Debrecen Debrecen Hungary"},{"name":"HCEMM Ltd. Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-5639","authenticated-orcid":false,"given":"Attila","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine University of Debrecen Debrecen Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-69375-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00725.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12298"},{"key":"e_1_2_8_6_1","first-page":"335","article-title":"Pellagra, a deficiency disease","volume":"93","author":"Elvehjem CA","year":"1949","journal-title":"Proc Am Philos Soc"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10163.x"},{"key":"e_1_2_8_8_1","first-page":"1539","article-title":"Dyssebacia: an early cutaneous marker of niacin deficiency","volume":"6","author":"Shashikiran AR","year":"2017","journal-title":"Int J Med Dent Sci"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/60.10.995"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.03.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.030833"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23626"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385952-5.00005-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.11.007"},{"key":"e_1_2_8_15_1","unstructured":"OffermannsS CollettiSL IJzermanAP et al.Hydroxycarboxylic acid receptors | G protein\u2010coupled receptors | IUPHAR\/BPS Guide to PHARMACOLOGY. 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