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PsO\u2010associated arthritis, known as psoriatic arthritis (PsA), develops in approximately 13%\u201025% of PsO patients. Various factors associated with both PsO and PsA indicate that these conditions are part of a single disease. Identification of novel targets for the development of drugs to treat both PsO and PsA is desirable to provide more patient\u2010friendly treatment regimens. Such targets will likely represent \u2018common checkpoints\u2019 of inflammation, for example key components or transduction cascades of the signalling pathways involved. Emerging evidence supports involvement of the non\u2010canonical Wnt signalling pathways in the development of both PsO and PsA, especially the Wnt5a\u2010activated signalling cascades. These, together with interlinked factors, are crucial in the interactions among keratinocytes, immune cells and inflammatory factors in PsO, as well as among chondrocytes, osteoblasts and osteoclasts that trigger both subchondral bone remodelling and cartilage catabolism in PsA. This review focuses on the pathological role of Wnt5a signalling and its interaction with other interlinked pathways in both PsO and PsA, and also on the main challenges for future research, particularly with respect to molecules targeting Wnt signalling pathways for the treatment of PsO and PsA.<\/jats:p>","DOI":"10.1111\/jcmm.14531","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T02:08:40Z","timestamp":1563329320000},"page":"5876-5883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The pathological role of Wnt5a in psoriasis and psoriatic arthritis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7083-3380","authenticated-orcid":false,"given":"Faming","family":"Tian","sequence":"first","affiliation":[{"name":"Medical Research Center North China University of Science and Technology Tangshan 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