{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:01:59Z","timestamp":1772992919981,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of this study was to investigate whether telmisartan protects the heart from the ischaemia\/reperfusion damage through a local microRNA\u20101 modulation. Studies on the myocardial ischaemia\/reperfusion injury in vivo and on the cardiomyocyte hypoxia\/reoxygenation damage in vitro were done. In vivo, male Sprague\u2010Dawley rats administered for 3\u00a0weeks with telmisartan 12\u00a0mg\/kg\/d by gastric gavage underwent ischaemia\/reperfusion of the left descending coronary artery. In these rats, infarct size measurement, ELISA, immunohistochemistry (IHC) and reverse transcriptase real\u2010time polymerase chain reaction showed that expressions of connexin 43, potassium voltage\u2010gated channel subfamily Q member 1 and the protein Bcl\u20102 were significantly increased by telmisartan in the reperfused myocardium, paralleled by microRNA\u20101 down\u2010regulation. In vitro, the transfection of cardiomyocytes with microRNA\u20101 reduced the expressions of connexin 43, potassium voltage\u2010gated channel subfamily Q member 1 and Bcl\u20102 in the cells. Telmisartan (50\u00a0\u00b5mol\/L) 60\u00a0minutes before hypoxia\/reoxygenation, while not affecting the levels of miR\u20101 in transfected cells in normoxic condition, almost abolished the increment of miR\u20101 induced by the hypoxia\/reoxygenation to transfected cells. All together, telmisartan cardioprotected against the myocardial damage through the microRNA\u20101 modulation, and consequent modifications of its downstream target connexin 43, potassium voltage\u2010gated channel subfamily Q member 1 and Bcl\u20102.<\/jats:p>","DOI":"10.1111\/jcmm.14534","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T09:31:56Z","timestamp":1564651916000},"page":"6635-6645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Telmisartan cardioprotects from the ischaemic\/hypoxic damage through a miR\u20101\u2010dependent pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Maria Consiglia","family":"Trotta","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine University of Campania \u2018Luigi Vanvitelli\u2019 Naples 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