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However, the in vitro and in vivo effects of Tan I on osteosarcoma (OS) remain inadequately elucidated, especially those against tumour metastasis. Our results showed that Tan I significantly inhibited OS cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro. Moreover, treatment with 10 and 20\u00a0mg\/kg Tan I effectively suppressed tumour growth in subcutaneous xenografts and orthotopic xenograft mouse models. In addition, Tan I significantly inhibited tumour metastasis in intracardiac inoculation xenograft models. The results also showed that Tan I\u2010induced increased expression of the proapoptotic gene Bax and decreased expression of the anti\u2010apoptotic gene Bcl\u20102 is the possible mechanism of its anti\u2010cancer effects. Tan I was also found to abolish the IL\u20106\u2010mediated activation of the JAK\/STAT3 signalling pathway. Conclusively, this study is the first to show that Tan I suppresses OS growth and metastasis in vitro and in vivo, suggesting it may be a potential novel and efficient drug candidate for the treatment of OS progression.<\/jats:p>","DOI":"10.1111\/jcmm.14539","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T01:10:52Z","timestamp":1562807452000},"page":"6454-6465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK\/STAT3 signalling pathway"],"prefix":"10.1111","volume":"23","author":[{"given":"Weiguo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The Third Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Li","sequence":"additional","affiliation":[{"name":"Department 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