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Studies revealed that miR\u201020b\u20103p is down\u2010regulated in hypercalciuric stone\u2010forming rat kidney. To investigate whether ADSC\u2010derived miR\u201020b\u20103p\u2010enriched exosomes protect against kidney stones, an ethylene glycol (EG)\u2010induced hyperoxaluria rat model and an in vitro model of oxalate\u2010induced NRK\u201052E cells were established to explore the protective mechanism of miR\u201020b\u20103p. The results showed that miR\u201020b\u20103p levels were decreased following hyperoxaluria in the urine of patients and in kidney tissues from animal models. Furthermore, treatment with miR\u201020b\u20103p\u2010enriched exosomes from ADSCs protected EG\u2010induced hyperoxaluria rats, and cell experiments confirmed that co\u2010culture with miR\u201020b\u20103p\u2010enriched exosomes alleviated oxalate\u2010induced cell autophagy and the inflammatory response by inhibiting ATG7 and TLR4. In conclusion, ADSC\u2010derived miR\u201020b\u20103p\u2010enriched exosomes protected against kidney stones by suppressing autophagy and inflammatory responses.<\/jats:p>","DOI":"10.1111\/jcmm.14555","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T02:00:03Z","timestamp":1567735203000},"page":"7268-7278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Exosomes from miR\u201020b\u20103p\u2010overexpressing stromal cells ameliorate calcium oxalate deposition in rat kidney"],"prefix":"10.1111","volume":"23","author":[{"given":"Jing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Urology, Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Urology, Dongzhimen Hospital Beijing University 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