{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:51:42Z","timestamp":1787611902484,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["NRF-2017R1A2B2009518"],"award-info":[{"award-number":["NRF-2017R1A2B2009518"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003648","name":"National Medical Center","doi-asserted-by":"publisher","award":["NMC2017-MS-06"],"award-info":[{"award-number":["NMC2017-MS-06"]}],"id":[{"id":"10.13039\/501100003648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peritoneal fibrosis (PF) is an intractable complication of peritoneal dialysis (PD) that leads to peritoneal membrane failure. This study investigated the role of suppression of tumorigenicity (ST)2 in PF using patient samples along with mouse and cell\u2010based models. Baseline dialysate soluble (s)ST2 level in patients measured 1\u00a0month after PD initiation was 2063.4\u00a0\u00b1\u00a02457.8\u00a0pg\/mL; patients who switched to haemodialysis had elevated sST2 levels in peritoneal effluent (1576.2\u00a0\u00b1\u00a0199.9\u00a0pg\/mL,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.03), which was associated with PD failure (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.04). Baseline sST2 showed good performance in predicting PD failure (area under the receiver operating characteristic curve\u00a0=\u00a00.780,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.001). In mice with chlorhexidine gluconate\u2010induced PF, ST2 was expressed in fibroblasts and mesothelial cells within submesothelial zones. In primary cultured human peritoneal mesothelial cells (HPMCs), transforming growth factor\u2010\u03b2 treatment increased ST2, fibronectin, \u03b2\u2010galactosidase and Snail protein levels and decreased E\u2010cadherin level. Anti\u2010ST2 antibody administration reversed the up\u2010regulation of ST2 and fibronectin expression; it also reduced fibrosis induced by high glucose (100\u00a0mmol\/L) in HPMCs. Thus, high ST2 level in dialysate is a marker for fibrosis and inflammation during peritoneal injury, and blocking ST2 may be an effective therapeutic strategy for renal preservation.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14571","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T08:57:27Z","timestamp":1565341047000},"page":"6872-6884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["ST2 blockade mitigates peritoneal fibrosis induced by TGF\u2010\u03b2 and high glucose"],"prefix":"10.1111","volume":"23","author":[{"given":"Yong Chul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Hong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunhwa","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010won","family":"Jo","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u2010seon","family":"Park","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodokhsuren","family":"Tsogbadrakh","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Nephrology Clinic National Cancer Center Ilsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Kidney Research Institute, Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook\u2010Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u2010Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Seoul National University College of Medicine and Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital Seoul Korea"},{"name":"Kidney Research Institute, Seoul National University Seoul Korea"},{"name":"Department of Medical Science Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran\u2010hui","family":"Cha","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine National Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8575-6610","authenticated-orcid":false,"given":"Seung Hee","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute, Seoul National University Hospital Seoul Korea"},{"name":"Kidney Research Institute, Seoul National University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"34","article-title":"Epithelial\u2010mesenchymal transition in fibrosing processes. 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