{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:10:22Z","timestamp":1788851422872,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81771336"],"award-info":[{"award-number":["81771336"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["U1704186"],"award-info":[{"award-number":["U1704186"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mild hypothermia and its key product, cold\u2010inducible protein RBM3, possess robust neuroprotective effects against various neurotoxins. However, we previously showed that mild hypothermia fails to attenuate the neurotoxicity from MPP\n                    <jats:sup>+<\/jats:sup>\n                    , one of typical neurotoxins related to the increasing risk of Parkinson disease (PD). To better understand the role of mild hypothermia and RBM3 in PD progression, another known PD\u2010related neurotoxin, rotenone (ROT) was utilized in this study. Using immunoblotting, cell viability assays and TUNEL staining, we revealed that mild hypothermia (32\u00b0C) significantly reduced the apoptosis induced by ROT in human neuroblastoma SH\u2010SY5Y cells, when compared to normothermia (37\u00b0C). Meanwhile, the overexpression of RBM3 in SH\u2010SY5Y cells mimicked the neuroprotective effects of mild hypothermia on ROT\u2010induced cytotoxicity. Upon ROT stimulation, MAPK signalling like p38, JNK and ERK, and AMPK and GSK\u20103\u03b2 signalling were activated. When RBM3 was overexpressed, only the activation of p38, JNK and ERK signalling was inhibited, leaving AMPK and GSK\u20103\u03b2 signalling unaffected. Similarly, mild hypothermia also inhibited the activation of MAPKs induced by ROT. Lastly, it was demonstrated that the MAPK (especially p38 and ERK) inhibition by their individual inhibitors significantly decreased the neurotoxicity of ROT in SH\u2010SY5Y cells. In conclusion, these data demonstrate that RBM3 mediates mild hypothermia\u2010related neuroprotection against ROT by inhibiting the MAPK signalling of p38, JNK and ERK.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14588","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T09:03:58Z","timestamp":1566464638000},"page":"7010-7020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cold\u2010inducible protein RBM3 mediates hypothermic neuroprotection against neurotoxin rotenone via inhibition on MAPK signalling"],"prefix":"10.1111","volume":"23","author":[{"given":"Hai\u2010Jie","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Xinxiang Medical University Xinxiang China"},{"name":"Henan Key Lab of Biological Psychiatry Second Affiliated Hospital of Xinxiang Medical University Xinxiang 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