{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:45:29Z","timestamp":1774442729357,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K09630"],"award-info":[{"award-number":["17K09630"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rheumatoid arthritis (RA)\u2010associated interstitial lung disease (ILD), a primary cause of mortality in patients with RA, has limited treatment options. A previously established RA model in D1CC transgenic mice aberrantly expressed major histocompatibility complex class II genes in joints, developing collagen II\u2010induced polyarthritis and anti\u2010cyclic citrullinated peptide antibodies and interstitial pneumonitis, similar to those in humans. Molecular hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) is an efficient antioxidant that permeates cell membranes and alleviates the reactive oxygen species\u2010induced injury implicated in RA pathogenesis. We used D1CC mice to analyse chronic lung fibrosis development and evaluate H\n                    <jats:sub>2<\/jats:sub>\n                    treatment effects. We injected D1CC mice with type II collagen and supplied them with H\n                    <jats:sub>2<\/jats:sub>\n                    \u2010rich or control water until analysis. Increased serum surfactant protein D values and lung densities images were observed 10\u00a0months after injection. Inflammation was patchy within the perilymphatic stromal area, with increased 8\u2010hydroxy\u20102\u02b9\u2010deoxyguanosine\u2010positive cell numbers and tumour necrosis factor\u2010\u03b1, BAX, transforming growth factor\u2010\u03b2, interleukin\u20106 and soluble collagen levels in the lungs. Inflammatory and fibrotic changes developed diffusely within the perilymphatic stromal area, as observed in humans. H\n                    <jats:sub>2<\/jats:sub>\n                    treatment decreased these effects in the lungs. Thus, this model is valuable for studying the effects of H\n                    <jats:sub>2<\/jats:sub>\n                    treatment and chronic interstitial pneumonia pathophysiology in humans. H\n                    <jats:sub>2<\/jats:sub>\n                    appears to protect against RA\u2010ILD by alleviating oxidative stress.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14603","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T06:21:25Z","timestamp":1566195685000},"page":"7043-7053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of H\n                    <sub>2<\/sub>\n                    treatment in a mouse model of rheumatoid arthritis\u2010associated interstitial lung disease"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4495-7982","authenticated-orcid":false,"given":"Yasuhiro","family":"Terasaki","sequence":"first","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Terasaki","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology Nagoya City University Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nariaki","family":"Kokuho","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-1963","authenticated-orcid":false,"given":"Hirokazu","family":"Urushiyama","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kajimoto","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Kunugi","sequence":"additional","affiliation":[{"name":"Department of Analytic Human Pathology, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyo","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Division of Laboratory Animal Science, Graduate School of Medicine Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Division of Laboratory Animal Science, Graduate School of Medicine Nippon Medical School 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