{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:11:52Z","timestamp":1791987112410,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470370"],"award-info":[{"award-number":["81470370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Idiopathic dilated cardiomyopathy (IDCM), characterized by ventricular dilation and impaired systolic function, is a primary cardiomyopathy resulting in heart failure. During heart contraction, the\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010line is responsible for transmitting force between sarcomeres and is also a hot spot for muscle cell signalling. Mutations in\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010line proteins have been linked to cardiomyopathies in both humans and mice. Actinin\u2010associated LIM protein (ALP) and enigma homolog protein (ENH), encoded by\n                    <jats:italic>PDLIM3<\/jats:italic>\n                    and\n                    <jats:italic>PDLIM5<\/jats:italic>\n                    , are components of the muscle cytoskeleton and localize to the\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010line. A\n                    <jats:italic>PDLIM3<\/jats:italic>\n                    or\n                    <jats:italic>PDLIM5<\/jats:italic>\n                    deficiency in mice leads to dilated cardiomyopathy. Since\n                    <jats:italic>PDLIM3<\/jats:italic>\n                    and\n                    <jats:italic>PDLIM5<\/jats:italic>\n                    are candidate IDCM susceptibility genes, the current study aims to investigate whether polymorphisms within\n                    <jats:italic>PDLIM3<\/jats:italic>\n                    and\n                    <jats:italic>PDLIM5<\/jats:italic>\n                    could be correlated with IDCM. We designed a case\u2010control study, and exons of the\n                    <jats:italic>PDLIM3<\/jats:italic>\n                    and\n                    <jats:italic>PDLIM5<\/jats:italic>\n                    were amplified by polymerase chain reactions in 111 IDCM patients and 137 healthy controls. We found that five synonymous polymorphisms had statistical distribution differences between IDCM patients and controls, including rs4861669, rs4862543, c.731\u00a0+\u00a0131\u00a0T\u00a0&gt;\u00a0G, c.1789\u20103 C\u00a0&gt;\u00a0T and rs7690296, according to genotype and allele distribution. Haplotype G\u2010C\u2010C\u2010C and A\u2010T\u2010C\u2010T (rs2306705, rs10866276, rs12644280 and rs4635850 synthesized) were regarded as risk factors for IDCM patients when compared with carriers of other haplotypes (all\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). Furthermore, IDCM patients with two novel polymorphisms (c.731\u00a0+\u00a0131\u00a0T\u00a0&gt;\u00a0G and c.1789\u20103 C\u00a0&gt;\u00a0T) had lower systolic blood pressure. In conclusion, these five synonymous polymorphisms might constitute a genetic background that increases the risk of the development of IDCM in the Chinese Han population.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14607","type":"journal-article","created":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T05:49:07Z","timestamp":1566193747000},"page":"7054-7062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Novel polymorphisms in\n                    <i>PDLIM3<\/i>\n                    and\n                    <i>PDLIM5<\/i>\n                    gene encoding\n                    <i>Z<\/i>\n                    \u2010line proteins increase risk of idiopathic dilated cardiomyopathy"],"prefix":"10.1111","volume":"23","author":[{"given":"Dongfei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 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