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Moreover, oxidative stress damage after tissue ischemia usually aggravated the progress of ED. As a new way of acellular therapy, mesenchymal stem cell\u2010derived exosomes (MSC\u2010Exos) have great potential in ED treatment. In the current study, we have explored the mechanism of MSC\u2010Exos therapy in a rat model of internal iliac artery injury\u2010induced ED. Compared with intracavernous (IC) injection of phosphate\u2010buffered saline after artery injury, of note, we observed that both mesenchymal stem cells (MSCs) and MSC\u2010Exos through IC injection could improve the erectile function to varying degrees. More\u00a0specifically, IC injection MSC\u2010Exos could promote cavernous sinus endothelial formation, reduce the organization oxidative stress damage, and improve the nitric oxide synthase and smooth muscle content in the corpus cavernosum. With similar potency compared with the stem cell therapy and other unique advantages, IC injection of MSC\u2010 Exos could be an effective treatment to ameliorate erectile function in a rat model of arterial injury.<\/jats:p>","DOI":"10.1111\/jcmm.14615","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T04:28:40Z","timestamp":1568262520000},"page":"7462-7473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Mesenchymal stem cell\u2010derived exosomes ameliorate erection by reducing oxidative stress damage of corpus cavernosum in a rat model of artery injury"],"prefix":"10.1111","volume":"23","author":[{"given":"Yangzhou","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology &amp; Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology The First Affiliated Hospital of Guangzhou Medical University Guangzhou 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