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The gene expression and DNA methylation profiles were analysed in different immune statuses of HBV infection. Differentially expressed genes (DEGs) and differentially methylated genes (DMGs) were identified, followed by their functional and integrative analyses. The differential expression of IgG Fc receptors (Fc\u03b3Rs) in chronic HBV\u2010infected patients and immune cells during different stages of HBV infection was investigated. Toll\u2010like receptor (TLR) signalling pathway (including TLR6) and leucocyte transendothelial migration pathway (including integrin subunit beta 1) were enriched during acute infection. Key DEGs, such as Fc\u03b3R Ib and Fc\u03b3R Ia, and interferon\u2010alpha inducible protein 27 showed correlation with alanine aminotransferase levels, and they were differentially expressed between acute and immune\u2010tolerant phases and between immune\u2010tolerant and immune\u2010clearance phases. The integrative analysis of DNA methylation profile showed that lowly methylated and highly expressed genes, including cytotoxic T lymphocyte\u2010associated protein 4 and mitogen\u2010activated protein kinase 3 were enriched in T cell receptor signalling pathway during acute infection. Highly methylated and lowly expressed genes, such as Ras association domain family member 1 and cyclin\u2010dependent kinase inhibitor 2A were identified in chronic infection. Furthermore, differentially expressed Fc\u03b3R Ia, Fc\u03b3R IIa and Fc\u03b3R IIb, CD3<jats:sup>\u2212<\/jats:sup>CD56<jats:sup>+<\/jats:sup>CD16<jats:sup>+<\/jats:sup> natural killer cells and CD14<jats:sup>high<\/jats:sup>CD16<jats:sup>+<\/jats:sup> monocytes were identified between immune\u2010tolerant and immune\u2010clearance phases by experimental validation. The above genes and pathways may be used to distinguish different immune statuses of HBV infection.<\/jats:p>","DOI":"10.1111\/jcmm.14616","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T22:29:14Z","timestamp":1569882554000},"page":"7474-7489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of key genes and pathways associated with different immune statuses of hepatitis B virus infection"],"prefix":"10.1111","volume":"23","author":[{"given":"Jinglan","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hepatology, The First Hospital of Jilin University Jilin University Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatology, The First Hospital of Jilin University Jilin University Changchun China"},{"name":"Jilin Province Key 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