{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:03:38Z","timestamp":1778861018449,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81672127"],"award-info":[{"award-number":["81672127"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81873986"],"award-info":[{"award-number":["81873986"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1908085QH317"],"award-info":[{"award-number":["1908085QH317"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that eventually leads to joint deformities and loss of joint function. Previous studies have demonstrated a close relationship between autophagy and the development of RA. Although autophagy and apoptosis are two different forms of programmed death, the relationship between them in relation to RA remains unclear. In this study, we explored the effect of autophagy on apoptosis of articular chondrocytes in vivo and in vitro. Adjuvant arthritis (AA) and acid\u2010induced primary articular chondrocyte apoptosis were used as in vivo and in vitro models, respectively. Articular chondrocyte autophagy and apoptosis were both observed dynamically in AA rat articular cartilage at different stages (15\u00a0days, 25\u00a0days and 35\u00a0days). Moreover, chondrocyte apoptosis and articular cartilage injury in AA rats were increased by the autophagy inhibitor 3\u2010methyladenine (3\u2010MA) and decreased by the autophagy activator rapamycin. In addition, pre\u2010treatment with 3\u2010MA increased acid\u2010induced chondrocyte apoptosis, while pre\u2010treatment with rapamycin reduced acid\u2010induced chondrocyte apoptosis in vitro. These results suggest that autophagy might be a potential target for the treatment of RA.<\/jats:p>","DOI":"10.1111\/jcmm.14629","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T11:10:23Z","timestamp":1568200223000},"page":"7879-7884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats"],"prefix":"10.1111","volume":"23","author":[{"given":"Renpeng","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology The Second Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoshan","family":"Wu","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujing","family":"Song","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"Dai","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Qian","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology The Second Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6778-8363","authenticated-orcid":false,"given":"Feihu","family":"Chen","sequence":"additional","affiliation":[{"name":"Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy Anhui Medical University Hefei China"},{"name":"The Key Laboratory of Anti\u2010inflammatory and Immune Medicine, Ministry of Education Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.10.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.142"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102808-114910"},{"key":"e_1_2_9_6_1","first-page":"35","article-title":"Apoptosis, autophagy, and necrosis in murine embryonic gonadal ridges and neonatal ovaries: an animal model","volume":"44","author":"Pajokh M","year":"2019","journal-title":"Iran J Med Sci"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02136"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203249"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0572-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.11.034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102125"},{"key":"e_1_2_9_12_1","first-page":"479","article-title":"Physiological and pathological significance of the molecular cross\u2010talk between autophagy and apoptosis","volume":"31","author":"Oral O","year":"2016","journal-title":"Histol Histopathol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.05.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1498"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1127-x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-015-1146-9"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2102"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T03:55:59Z","timestamp":1692244559000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jcmm.14629"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14629","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,11]]},"assertion":[{"value":"2019-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}