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However, various hepatotoxic factors including infection, chemicals, high\u2010fat diet consumption, surgical procedures and genetic mutations, as well as biliary tract diseases such as sclerosing cholangitis and bile duct ligation, ultimately progress into liver cirrhosis after activation of fibrogenesis. Melatonin (MT), a special hormone isolated from the pineal gland, participates in regulating multiple physiological functions including sleep promotion, circadian rhythms and neuroendocrine processes. Current evidence shows that MT protects against liver injury by inhibiting oxidation, inflammation, HSC proliferation and hepatocyte apoptosis, thereby inhibiting the progression of liver cirrhosis. In this review, we summarize the circadian rhythm of liver cirrhosis and its potential mechanisms as well as the therapeutic effects of MT on liver cirrhosis and earlier\u2010stage liver diseases including liver steatosis, nonalcoholic fatty liver disease and liver fibrosis. Given that MT is an antioxidative and anti\u2010inflammatory agent that is effective in eliminating liver injury, it is a potential agent with which to reverse liver cirrhosis in its early stage.<\/jats:p>","DOI":"10.1111\/jcmm.14634","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T09:06:01Z","timestamp":1567415161000},"page":"7151-7162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Protective role of melatonin in early\u2010stage and end\u2010stage liver cirrhosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Chenxia","family":"Hu","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital Zhejiang University Hangzhou Zhejiang 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