{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T21:34:40Z","timestamp":1774906480261,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T00:00:00Z","timestamp":1569715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301507"],"award-info":[{"award-number":["81301507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic cardiomyopathy is characterized by diabetes\u2010induced myocardial abnormalities, accompanied by inflammatory response and alterations in inflammation\u2010related signalling pathways. Kirenol, isolated from <jats:italic>Herba Siegesbeckiae<\/jats:italic>, has potent anti\u2010inflammatory properties. In this study, we aimed to investigate the cardioprotective effect of kirenol against DCM and underlying the potential mechanisms in a type 2 diabetes mellitus model. Kirenol treatment significantly decreased high glucose\u2010induced cardiofibroblasts proliferation and increased the cardiomyocytes viability, prevented the loss of mitochondrial membrane potential and further attenuated cardiomyocytes apoptosis, accompanied by a reduction in apoptosis\u2010related protein expression. Kirenol gavage could affect the expression of pro\u2010inflammatory cytokines in a dose\u2010dependent manner but not lower lipid profiles, and only decrease fasting plasma glucose, fasting plasma insulin and mean HbA1c levels in high\u2010dose kirenol\u2010treated group at some time\u2010points. Left ventricular dysfunction, hypertrophy, fibrosis and cell apoptosis, as structural and functional abnormalities, were ameliorated by kirenol administration. Moreover, in diabetic hearts, oral kirenol significantly attenuated activation of mitogen\u2010activated protein kinase subfamily and nuclear translocation of NF\u2010\u03baB and Smad2\/3 and decreased phosphorylation of I\u03baB\u03b1 and both fibrosis\u2010related and apoptosis\u2010related proteins. In an Electrophoretic mobility shift assay, the binding activities of NF\u2010\u03baB, Smad3\/4, SP1 and AP\u20101 in the nucleus of diabetic myocardium were significantly down\u2010regulated by kirenol treatment. Additionally, high dose significantly enhanced myocardial Akt phosphorylation without intraperitoneal injection of insulin. Kirenol may have potent cardioprotective effects on treating for the established diabetic cardiomyopathy, which involves the inhibition of inflammation and fibrosis\u2010related signalling pathways and is independent of lowering hyperglycaemia, hyperinsulinemia and lipid profiles.<\/jats:p>","DOI":"10.1111\/jcmm.14638","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T18:06:11Z","timestamp":1569866771000},"page":"7651-7663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model"],"prefix":"10.1111","volume":"23","author":[{"given":"Bin","family":"Wu","sequence":"first","affiliation":[{"name":"Laboratory of Platelet and Endothelium Biology, Department of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Transfusion Medicine, the Third Xiangya Hospital Central South University Changsha China"},{"name":"Department of Physiology and Pharmacology, Medical College Hubei University of Arts and Science Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, the Third Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the Third Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng\u2010Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Platelet and Endothelium Biology, Department of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan\u2010Qi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Medical College Hubei University of Arts and Science Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, the Third Xiangya Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1879-6671","authenticated-orcid":false,"given":"Shun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Platelet and Endothelium Biology, Department of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0383-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679597"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008788"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226928"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306923"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.216"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.86"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-17-0681"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8214541"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.06.037"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09022"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1610.10050"},{"key":"e_1_2_10_15_1","first-page":"148","article-title":"Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells","volume":"69","author":"Lu Y","year":"2014","journal-title":"Pharmazie"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.017"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-010-9182-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.185686"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.12.031"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2013.10.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9401-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072080"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx011"},{"key":"e_1_2_10_25_1","first-page":"1283","article-title":"Protective effect of angiotensin\u2010(1\u20137) against hyperglycaemia\u2010induced injury in H9c2 cardiomyoblast cells via the PI3KAkt signaling pathway","volume":"41","author":"Yang YY","year":"2018","journal-title":"Int J Mol Med"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2005.08.001"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1938"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.12.1123"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00702-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0867"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661405"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.22.2668"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.10.2791"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00268-9"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000057810.48709.F6"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.11.004"},{"issue":"2","key":"e_1_2_10_37_1","first-page":"CD002948","article-title":"Herbal therapy for treating rheumatoid arthritis","author":"Cameron M","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01305.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8562528"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.04.010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1577"},{"key":"e_1_2_10_43_1","first-page":"425","article-title":"Advances in NF\u2010kappaB signaling transduction and transcription","volume":"1","author":"Xiao W","year":"2004","journal-title":"Cell Mol Immunol"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.150"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1385\/CT:3:3:229"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00251.2013"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23097"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300913"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0502-e131"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T03:54:10Z","timestamp":1692244450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,29]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jcmm.14638"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14638","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,29]]},"assertion":[{"value":"2019-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}