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Air pollution exposure during pregnancy poses potential threat to offspring as the deleterious substances might pass through placenta to alter foetal development. A growing number of studies have demonstrated that long non\u2010coding RNAs (lncRNAs) participate in the development of many diseases, including congenital defects. Here, we used RNA sequencing to identify differentially expressed lncRNAs in air pollution\u2010exposed rat embryos compared with control group. Our data suggested that 554 lncRNAs (216 up\u2010regulated and 338 down\u2010regulated) were significantly differentially expressed in the air pollution\u2010exposed embryos. Moreover, potential cellular functions of these deregulated lncRNAs were predicted via KEGG signal pathway\/GO enrichment analyses, which suggested the possible involvements of neurological process, sensory perception of smell and the G\u2010protein signalling pathway. Furthermore, potential functional network of deregulated lncRNAs and their correlated mRNAs in the development of congenital spinal abnormality was established. Our data suggested that lncRNAs may play a vital role in the pathophysiology of air pollution\u2010exposed congenital spinal malformation.<\/jats:p>","DOI":"10.1111\/jcmm.14645","type":"journal-article","created":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T02:26:46Z","timestamp":1569551206000},"page":"7717-7725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Aberrantly expressed long non\u2010coding RNAs in air pollution\u2010induced congenital defects"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-0194","authenticated-orcid":false,"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery The General Hospital of Xingtai Mining Industry Bloc. Orthopaedic Hospital of Xingtai Xingtai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingye","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Beijing Jishuitan Hospital Fourth Clinical College of Peking University Jishuitan Orthopaedic College of Tsinghua University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T. V.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-4913","authenticated-orcid":false,"given":"William K. 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