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We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells\u2019 proliferation, increased expression of DNA damage marker \u03b3H2AX, induced cell cycle arrest and decreased cyclin D1 level. Treatment of MCL cell lines with dimethyloxalylglycine, which blocks dioxygenases involving PHDs by competing with their substrate 2\u2010oxoglutarate, leads to their decreased proliferation and the decrease of cyclin D1 level. We then postulated that loss of <jats:italic>EGLN2<\/jats:italic>\/PHD1 in MCL cells may lead to down\u2010regulation of cyclin D1 by blocking the degradation of FOXO3A, a cyclin D1 suppressor. However, the CRISPR\/Cas9\u2010based loss\u2010of\u2010function of <jats:italic>EGLN2<\/jats:italic>\/PHD1 did not affect cyclin D1 expression and the loss of FOXO3A did not restore cyclin D1 levels after iron chelation. These data suggest that expression of cyclin D1 in MCL is not controlled by <jats:italic>ENGL2<\/jats:italic>\/PHD1\u2010FOXO3A pathway and that chelation\u2010 and 2\u2010oxoglutarate competition\u2010mediated down\u2010regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron\u2010 and 2\u2010oxoglutarate\u2010dependent dioxygenases other than PHD1. These data support further exploration of the use of iron chelation and 2\u2010oxoglutarate\u2010dependent dioxygenase inhibitors as a novel therapy of MCL.<\/jats:p>","DOI":"10.1111\/jcmm.14655","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:11:36Z","timestamp":1568369496000},"page":"7785-7795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Iron chelation and 2\u2010oxoglutarate\u2010dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1"],"prefix":"10.1111","volume":"23","author":[{"given":"Olga","family":"Babosova","sequence":"first","affiliation":[{"name":"Department of Cell and Developmental Biology Institute of Molecular Genetics Academy of Sciences of the Czech Republic Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Kapralova","sequence":"additional","affiliation":[{"name":"Department 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