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We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of <jats:italic>Schistosoma japonicum<\/jats:italic>. SJMHE1 can inhibit delayed\u2010type hypersensitivity and collagen\u2010induced arthritis in mice. In the present study, we evaluated this peptide's potential intervention effect and mechanism on ovalbumin\u2010induced asthma in mice. SJMHE1 treatment suppressed airway inflammation in allergic mice, decreased the infiltrating inflammatory cells in the lungs and bronchoalveolar lavage fluid, modulated the production of pro\u2010inflammatory and anti\u2010inflammatory cytokines in the splenocytes and lungs of allergic mice, reduced the percentage of Th2 cells and increased the proportion of Th1 and regulatory T cells (Tregs). At the same time, Foxp3 and T\u2010bet expression increased, and GATA3 and ROR\u03b3t decreased in the lungs of allergic mice. We proved that SJMHE1 can interrupt the development of asthma by diminishing airway inflammation in mice. The down\u2010regulation of Th2 response and the up\u2010regulation of Th1 and Tregs response may contribute to the protection induced by SJMHE1 in allergic mice. SJMHE1 can serve as a novel therapy for asthma and other allergic or inflammatory diseases.<\/jats:p>","DOI":"10.1111\/jcmm.14661","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T08:14:43Z","timestamp":1568016883000},"page":"7819-7829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Schistosoma japonicum<\/i> peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Wenzhe","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Central Laboratory The Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory The Affiliated Hospital of Jiangsu University Zhenjiang 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