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An elevated level of ROS is a salient feature of ischaemia\u2010reperfusion, chronic cerebral hypo\u2010perfusion and neonatal hypoxia\u2010ischaemia. The TRPM2 channel is expressed in hippocampus, cortex and striatum, the brain regions that are critical for cognitive functions. In this review, we examine the recent studies that combine pharmacological and\/or genetic interventions with using in vitro and in vivo models to demonstrate a crucial role of the TRPM2 channel in brain damage by ischaemia\u2010reperfusion, chronic cerebral hypo\u2010perfusion and neonatal hypoxic\u2010ischaemia. We also discuss the current understanding of the underlying TRPM2\u2010dependent cellular and molecular mechanisms. These new findings lead to the hypothesis of targeting the TRPM2 channel as a potential novel therapeutic strategy to alleviate brain damage and cognitive dysfunction caused by these conditions.<\/jats:p>","DOI":"10.1111\/jcmm.14679","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:21:52Z","timestamp":1569907312000},"page":"4-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["TRPM2 channel: A novel target for alleviating ischaemia\u2010reperfusion, chronic cerebral hypo\u2010perfusion and neonatal hypoxic\u2010ischaemic brain damage"],"prefix":"10.1111","volume":"24","author":[{"given":"Chendi","family":"Mai","sequence":"first","affiliation":[{"name":"Sino\u2010UK Joint Laboratory of Brian Function and Injury of Henan Province and Department of Physiology and Neurobiology Xinxiang Medical University Xinxiang China"},{"name":"Sanquan College of Xinxiang Medical University 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