{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T19:52:58Z","timestamp":1793994778651,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573759"],"award-info":[{"award-number":["81573759"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Long noncoding RNA (lncRNA) has been suggested to play an important role in a variety of diseases over the past decade. In a previous study, we identified a novel lncRNA, termed HOXA11\u2010AS, which was significantly up\u2010regulated in calcium oxalate (CaOx) nephrolithiasis. However, the biological function of HOXA11\u2010AS in CaOx nephrolithiasis remains poorly defined. Here, we demonstrated that HOXA11\u2010AS was significantly up\u2010regulated in CaOx nephrolithiasis both in vivo and in vitro. Gain\u2010\/loss\u2010of\u2010function studies revealed that HOXA11\u2010AS inhibited proliferation, promoted apoptosis and aggravated cellular damage in HK\u20102 cells exposed to calcium oxalate monohydrate (COM). Further investigations showed that HOXA11\u2010AS regulated monocyte chemotactic protein 1 (MCP\u20101) expression in HK\u20102 cell model of CaOx nephrolithiasis. In addition, online bioinformatics analysis and dual\u2010luciferase reporter assay results showed that miR\u2010124\u20103p directly bound to HOXA11\u2010AS and the 3'UTR of MCP\u20101. Furthermore, rescue experiment results revealed that HOXA11\u2010AS functioned as a competing endogenous RNA to regulate MCP\u20101 expression through sponging miR\u2010124\u20103p and that overexpression of miR\u2010124\u20103p restored the inhibitory effect of proliferation, promotion effects of apoptosis and cell damage induced by HOXA11\u2010AS overexpression. Taken together, HOXA11\u2010AS mediated CaOx crystal\u2013induced renal inflammation via the miR\u2010124\u20103p\/MCP\u20101 axis, and this outcome may provide a good potential therapeutic target for nephrolithiasis.<\/jats:p>","DOI":"10.1111\/jcmm.14706","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T01:52:46Z","timestamp":1572832366000},"page":"238-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["LncRNA HOXA11\u2010AS regulates calcium oxalate crystal\u2013induced renal inflammation via miR\u2010124\u20103p\/MCP\u20101"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-6103","authenticated-orcid":false,"given":"Yinhui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology Changhai Hospital The Naval Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiling","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery Changhai Hospital The Naval Military Medical University Shanghai China"},{"name":"Department of General Surgery The Naval Hospital Eastern Theater PLA Zhoushan Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Changhai Hospital The Naval Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology Changhai Hospital The Naval Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology Changhai Hospital The 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