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In the present study, we demonstrated that acute MI rats that underwent early moderate exercise training beginning one day after MI showed no increase in mortality and displayed significant improvements in MI healing and ventricular remodelling, including an improvement in cardiac function, a decrease in infarct size, cardiomyocyte apoptosis, cardiac fibrosis and cardiomyocyte hypertrophy, and an increase in myocardial angiogenesis, left ventricular wall thickness and the number of cardiac telocytes in the border zone. Integrated miRNA\u2010mRNA profiling analysis performed by the ingenuity pathway analysis system revealed that the inhibition of the TGFB1 regulatory network, activation of leucocytes and migration of leucocytes into the infarct zone comprise the molecular mechanism underlying early moderate exercise\u2010mediated improvements in cardiac fibrosis and the pathological inflammatory response. The findings of the present study demonstrate that early moderate exercise training beginning one day after MI is safe and leads to significantly enhanced MI healing and ventricular remodelling. Understanding the mechanism behind the positive effects of this early training protocol will help us to further tailor suitable cardiac rehabilitation programmes for humans.<\/jats:p>","DOI":"10.1111\/jcmm.14710","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T08:50:31Z","timestamp":1571129431000},"page":"8328-8342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Early moderate exercise benefits myocardial infarction healing via improvement of inflammation and ventricular remodelling in rats"],"prefix":"10.1111","volume":"23","author":[{"given":"Zhaofu","family":"Liao","sequence":"first","affiliation":[{"name":"Key Laboratory of Regenerative Medicine Ministry of Education Jinan University Guangzhou China"},{"name":"Joint Laboratory for Regenerative Medicine Chinese University of Hong Kong\u2010Jinan University Guangzhou China"},{"name":"International Base of Collaboration 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