{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:27:10Z","timestamp":1790072830420,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Grant of Bengbu Medical College","award":["BYKF18104"],"award-info":[{"award-number":["BYKF18104"]}]},{"name":"Guangdong Provincial People's Hospital Grant for Talent Introduction","award":["Y012018144"],"award-info":[{"award-number":["Y012018144"]}]},{"name":"National Natural Science Grant of China","award":["81500207"],"award-info":[{"award-number":["81500207"]}]},{"name":"National Natural Science Grant of China","award":["81700259"],"award-info":[{"award-number":["81700259"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cardiac protection of mesenchymal stem cell (MSC) transplantation for myocardial infarction (MI) is largely hampered by low cell survival. Haem oxygenase 1 (HO\u20101) plays a critical role in regulation of cell survival under many stress conditions. This study aimed to investigate whether pre\u2010treatment with haemin, a potent HO\u20101 inducer, would promote the survival of MSCs under serum deprivation and hypoxia (SD\/H) and enhance the cardioprotective effects of MSCs in MI. Bone marrow (BM)\u2010MSCs were pretreated with or without haemin and then exposed to SD\/H. The mitochondrial morphology of MSCs was determined by MitoTracker staining. BM\u2010MSCs and haemin\u2010pretreated BM\u2010MSCs were transplanted into the peri\u2010infarct region in MI mice. SD\/H induced mitochondrial fragmentation, as shown by increased mitochondrial fission and apoptosis of BM\u2010MSCs. Pre\u2010treatment with haemin greatly inhibited SD\/H\u2010induced mitochondrial fragmentation and apoptosis of BM\u2010MSCs. These effects were partially abrogated by knocking down HO\u20101. At 4\u00a0weeks after transplantation, compared with BM\u2010MSCs, haemin\u2010pretreated BM\u2010MSCs had greatly improved the heart function of mice with MI. These cardioprotective effects were associated with increased cell survival, decreased cardiomyocytes apoptosis and enhanced angiogenesis. Collectively, our study identifies haemin as a regulator of MSC survival and suggests a novel strategy for improving MSC\u2010based therapy for MI.<\/jats:p>","DOI":"10.1111\/jcmm.14747","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T09:40:33Z","timestamp":1572342033000},"page":"431-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Haemin pre\u2010treatment augments the cardiac protection of mesenchymal stem cells by inhibiting mitochondrial fission and improving survival"],"prefix":"10.1111","volume":"24","author":[{"given":"Rui","family":"Deng","sequence":"first","affiliation":[{"name":"Department of General Surgery The Second Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Bengbu Medical College Bengbu 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