{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:40:48Z","timestamp":1790224848152,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81570514"],"award-info":[{"award-number":["81570514"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81600466"],"award-info":[{"award-number":["81600466"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81770585"],"award-info":[{"award-number":["81770585"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770585"],"award-info":[{"award-number":["81770585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Autoimmune hepatitis (AIH) is a chronic liver disease due to autoimmune system attacks hepatocytes and causes inflammation and fibrosis. Intracellular signalling and miRNA may play an important role in regulation of liver injury. This study aimed to investigate the potential roles of microRNA 143 in a murine AIH model and a hepatocyte injury model. Murine AIH model was induced by hepatic antigen S100, and hepatocyte injury model was induced by LPS. Mice and AML12 cells were separated into six groups with or without the treatment of miRNA\u2010143. Inflammation and fibrosis as well as gene expression were examined by different cellular and molecular techniques. The model was successfully established with the elevation of ALT and AST as well as inflammatory and fibrotic markers. Infection or transfection of mir\u2010143 in mice or hepatocytes significantly attenuated the development of alleviation of hepatocyte injury. Moreover, the study demonstrated phosphorylation of TAK1\u2010mediated miRNA\u2010143 regulation of hepatic inflammation and fibrosis as well as hepatocyte injury. Our studies demonstrated a significant role of miRNA\u2010143 in attenuation of liver injury in AIH mice and hepatocytes. miRNA\u2010143 regulates inflammation and fibrosis through its regulation of TAK1 phosphorylation, which warrants TAK1 as a target for the development of new therapeutic strategy of autoimmune hepatitis.<\/jats:p>","DOI":"10.1111\/jcmm.14750","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T07:49:33Z","timestamp":1575618573000},"page":"1256-1267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["microRNA\u2010143\u20103p attenuated development of hepatic fibrosis in autoimmune hepatitis through regulation of TAK1 phosphorylation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-1099","authenticated-orcid":false,"given":"Hanxiao","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Hospital of Peking University BeiJing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"},{"name":"Department of Infectious Diseases The Affiliated Yiwu Central Hospital of Wenzhou Medical University Yiwu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuedong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanman","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"},{"name":"Department of Infectious Diseases and Liver Diseases Ningbo Medical Center Lihuili Hospital Ningbo China"},{"name":"Department of Infectious Diseases and Liver Diseases The Affiliated Lihuili Hospital of Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3721-8180","authenticated-orcid":false,"given":"Yongping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Wenzhou Key Laboratory of Hepatology The First Affiliated Hospital of Wenzhou Medical University Hepatology Institute of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200405000-00007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34944"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23584"},{"key":"e_1_2_8_5_1","first-page":"263","article-title":"Mortality and causes of death in patients with \"lupoid hepatitis.\" A long\u2010term follow\u2010up study in Denmark","volume":"49","author":"Poulsen LO","year":"2002","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_6_1","first-page":"749","article-title":"Predictive factors for remission and death in 73 patients with autoimmune hepatitis in Japan","volume":"11","author":"Hino T","year":"2003","journal-title":"Int J Mol Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.03.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2699-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12329"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23124"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26581"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12416"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.03.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35085597"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1360605"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/18465"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2749"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270611"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2015.0037"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldv021"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32485"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.065"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.06.030"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30031"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.235259"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.11.008"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.08.005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04831-3"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.075"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.108"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.003"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.10.1198"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-1554"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.04.007"},{"issue":"765","key":"e_1_2_8_38_1","first-page":"e4","article-title":"Cell death and cell death responses in liver disease: mechanisms and clinical relevance","volume":"147","author":"Luedde T","year":"2014","journal-title":"Gastroenterology"},{"issue":"323","key":"e_1_2_8_39_1","first-page":"e7","article-title":"Toll\u2010like receptor 9 promotes steatohepatitis by induction of interleukin\u20101beta in mice","volume":"139","author":"Miura K","year":"2010","journal-title":"Gastroenterology"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.01.009"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.303970"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1181"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32372"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14489"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30485"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.14750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:01:11Z","timestamp":1788447671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,6]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/jcmm.14750"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14750","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,6]]},"assertion":[{"value":"2019-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}