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Previous studies have demonstrated that curcumin has a protective effect on bone disorders and inflammatory diseases and can ameliorate polymethylmethacrylate\u2010induced osteolysis in vivo. However, the effect on immunomodulation and the definitive mechanism by which curcumin reduces the receptor activators of nuclear factor\u2010kappa B ligand (RANKL)\u2010stimulated osteoclast formation and prevents the activation of osteoclastic signalling pathways are unclear. In this work, the immunomodulation effect and anti\u2010osteoclastogenesis capacities exerted by curcumin on titanium nanoparticle\u2010stimulated macrophage polarization and on RANKL\u2010mediated osteoclast activation and differentiation in osteoclastic precursor cells in vitro were investigated. As expected, curcumin inhibited RANKL\u2010stimulated osteoclast maturation and formation and had an immunomodulatory effect on macrophage polarization in vitro. Furthermore, studies aimed to identify the potential molecular and cellular mechanisms revealed that this protective effect of curcumin on osteoclastogenesis occurred through the amelioration of the activation of Akt\/NF\u2010\u03baB\/NFATc1 pathways. Additionally, an in vivo mouse calvarial bone destruction model further confirmed that curcumin ameliorated the severity of titanium nanoparticle\u2010stimulated bone loss and destruction. Our results conclusively indicated that curcumin, a major biologic component of\n                    <jats:italic>Curcuma longa<\/jats:italic>\n                    with anti\u2010inflammatory and immunomodulatory properties, may serve as a potential therapeutic agent for osteoclastic diseases.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14842","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T03:32:42Z","timestamp":1576553562000},"page":"1553-1567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Curcumin has immunomodulatory effects on RANKL\u2010stimulated osteoclastogenesis in vitro and titanium nanoparticle\u2010induced bone loss in vivo"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-4691","authenticated-orcid":false,"given":"Chao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedics 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