{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:24:22Z","timestamp":1788449062898,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01 GM087285\u201005A1"],"award-info":[{"award-number":["2R01 GM087285\u201005A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["123336"],"award-info":[{"award-number":["123336"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001805","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["25407"],"award-info":[{"award-number":["25407"]}],"id":[{"id":"10.13039\/501100001805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prolonged and persistent hypermetabolism and excessive inflammatory response after severe trauma is detrimental and associated with poor outcome. The predisposing pathology or signals mediating this complex response are essentially unknown. As the liver is the central organ mediating the systemic metabolic responses and considering that adult hepatic stem cells are on top of the hierarchy of cell differentiation and may pass epigenetic information to their progeny, we asked whether liver progenitor cells are activated, signal hypermetabolism upon post\u2010traumatic cellular stress responses, and pass this to differentiated progeny. We generated Sox9CreER\n                    <jats:sup>T2<\/jats:sup>\n                    : ROSA26 EYFP mice to lineage\u2010trace the periportal ductal progenitor cells (PDPCs) and verify the fate of these cells post\u2010burn. We observed increased proliferation of PDPCs and their progeny peaking around two weeks post\u2010burn, concomitant with the hepatomegaly and the cellular stress responses. We then sorted out PDPCs, PDPC\u2010derived hepatocytes and mature hepatocytes, compared their transcriptome and showed that PDPCs and their progeny present a significant up\u2010regulation in signalling pathways associated with inflammation and metabolic activation, contributing to persistent hypermetabolic and hyper\u2010inflammatory state. Furthermore, concomitant down\u2010regulation of LXR signalling in PDPCs and their progeny implicates the therapeutic potential of early and short\u2010term administration of LXR agonists in ameliorating such persistent hypermetabolism.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14845","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T07:15:10Z","timestamp":1575357310000},"page":"1578-1587","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma"],"prefix":"10.1111","volume":"24","author":[{"given":"Li","family":"Diao","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusef","family":"Yousuf","sequence":"additional","affiliation":[{"name":"Sunnybrook 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