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Here, we investigated a method to establish functional and stable neovessel networks to increase plaque stability. Rabbits underwent aortic balloon injury and were divided into six groups: sham, vector and lentiviral transfection with vascular endothelial growth factor\u2010A (VEGF)\u2010A, fibroblast growth factor (FGF)\u20102, platelet\u2010derived growth factor (PDGF)\u2010BB and FGF\u20102\u00a0+\u00a0PDGF\u2010BB. Lentivirus was percutaneously injected into the media\u2010adventitia of the abdominal aorta by intravascular ultrasound guidance, and plaque\u2010rupture rate, plaque\u2010vulnerability index and plaque neovessel density at the injection site were evaluated. Confocal microscopy, Prussian Blue assay, Evans Blue, immunofluorescence and transmission electron microscopy were used to assess neovessel function and pericyte coverage. To evaluate the effect of FGF\u20102\/PDGF\u2010BB on pericyte migration, we used the mesenchymal progenitor cell line 10T1\/2 as an in vitro model. VEGF\u2010A\u2010 and FGF\u20102\u2010overexpression increased the number of immature neovessels, which caused intraplaque haemorrhage and inflammatory cell infiltration, eventually resulting in the plaque vulnerability; however, FGF\u20102\/PDGF\u2010BB induced mature and functional neovessels, through increased neovessel pericyte coverage. Additionally, in vitro analysis of 10T1\/2 cells revealed that FGF\u20102\/PDGF\u2010BB induced <jats:italic>epsin\u20102<\/jats:italic> expression and enhanced the VEGF receptor\u20102 degradation, which negatively regulated pericyte function consistent with the in vivo data. These results showed that the combination of FGF\u20102 and PDGF\u2010BB promoted the function and maturation of plaque neovessels, thereby representing a novel potential treatment strategy for vulnerable plaques.<\/jats:p>","DOI":"10.1111\/jcmm.14850","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T04:15:05Z","timestamp":1574396105000},"page":"1128-1140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Fibroblast growth factor\u20102\/platelet\u2010derived growth factor enhances atherosclerotic plaque stability"],"prefix":"10.1111","volume":"24","author":[{"given":"Yang","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Gang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-5614","authenticated-orcid":false,"given":"Xing Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan 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