{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:25:24Z","timestamp":1788449124172,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to explore the underlying mechanism of linc01014 in oesophagus cancer gefitinib resistance. Gefitinib\u2010resistant oesophagus squamous cell carcinoma (ESCC gefitinibR) cell lines were constructed by using different gefitinib treatment in FLO\u20101, KYAE\u20101, TE\u20108 and TE\u20105 cell lines and confirmed by MTS50 and proliferation assays. Expression of linc01014 was overexpressed\/silenced in FLO\u20101 cells followed by gefitinib treatment, and then, the apoptosis\u2010associated markers Bax and Bcl\u20102, and PI3KCA in PI3K signalling pathway were determined using Western blotting. MST50 and morphology analyses showed that ESCC gefitinibR cell lines presented obvious gefitinib resistance than their parental ESCC cell lines. ESCC gefitinibR cell lines showed significantly higher proliferation abilities than their parental ESCC cell lines after treating with gefitinib. Overexpression of linc01014 significantly inhibited the apoptosis of FLO\u20101 cells induced by gefitinib and silencing linc01014 obviously promoted the apoptosis of FLO\u20101 cells induced by gefitinib. Silencing linc01014 could significantly increase the gefitinib chemotherapy sensitivity of oesophagus cancer via PI3K\u2010AKT\u2010mTOR signalling pathway.<\/jats:p>","DOI":"10.1111\/jcmm.14860","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T05:10:23Z","timestamp":1575263423000},"page":"1670-1675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Linc01014 regulates gefitinib resistance in oesophagus cancer via EGFR\u2010PI3K\u2010AKT\u2010mTOR signalling pathway"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiao","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The First Affliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affliated Hospital of 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