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Osteoclasts, originating from the monocyte\/macrophage lineage, are the only cell type possessing bone resorption ability. Osteoclast overactivity is thought to be the major reason underlying osteoclast\u2010related osteolytic problems, such as Paget's disease, aseptic loosening of prostheses and inflammatory osteolysis; therefore, disruption of osteoclastogenesis is considered a crucial treatment option for these issues. WKYMVm, a synthetic peptide, which is a potent FPR2 agonist, exerts\u00a0an immunoregulatory effect. This peptide inhibits the production of inflammatory cytokines, such as (IL)\u20101\u03b2 and TNF\u2010\u03b1, thus regulating inflammation. However, there are only few reports on the role of WKYMVm and FPR2 in osteoclast cytology. In the current study, we found that WKYMVm negatively regulates RANKL\u2010 and lipopolysaccharide (LPS)\u2010induced osteoclast differentiation and maturation in vitro and alleviates LPS\u2010induced osteolysis in animal models. WKYMVm down\u2010regulated the expression of osteoclast marker genes and resorption activity. Furthermore, WKYMVm inhibited osteoclastogenesis directly through reducing the phosphorylation of STAT3 and NF\u2010kB and indirectly through the CD9\/gp130\/STAT3 pathway. In conclusion, our findings demonstrated the potential medicinal value of WKYMVm for the treatment of inflammatory osteolysis.<\/jats:p>","DOI":"10.1111\/jcmm.14885","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T06:26:15Z","timestamp":1576304775000},"page":"1893-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF\u2010\u03baB and CD9\/gp130\/STAT3 signalling pathway"],"prefix":"10.1111","volume":"24","author":[{"given":"Junxian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Southwest Hospital Army Medical University (Third Military Medical University) Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghe","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou Medical University Guiyang 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