{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:12:37Z","timestamp":1781759557108,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Double Hundred Program for Shenyang Scientific and Technological Innovation Projects","award":["Z18-4-020"],"award-info":[{"award-number":["Z18-4-020"]}]},{"name":"Double Hundred Program for Shenyang Scientific and Technological Innovation Projects","award":["100040"],"award-info":[{"award-number":["100040"]}]},{"name":"National Natural Science Foundation of China and Liaoning joint fund key program","award":["U1608281"],"award-info":[{"award-number":["U1608281"]}]},{"name":"Post-doctoral research start-up funding","award":["1210618017"],"award-info":[{"award-number":["1210618017"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing evidence has verified that small nucleolar RNAs (snoRNAs) play significant roles in tumorigenesis and exhibit prognostic value in clinical practice. In the study, we analysed the expression profile and clinical relevance of snoRNAs from TCGA database including 530 ccRCC (clear cell renal cell carcinoma) and 72 control cases. By using univariate and multivariate Cox analysis, we established a six\u2010snoRNA signature and divided patients into high\u2010risk or low\u2010risk groups. We found patients in high\u2010risk group had significantly shorter overall survival and recurrence\u2010free survival than those in low\u2010risk group in test series, validation series and entire series by Kaplan\u2010Meier analysis. We also confirmed this signature had a great accuracy and specificity in 64 clinical tissue cases and 50 serum samples. Then, depending on receiver operating characteristic curve analysis we found the six\u2010snoRNA signature was an superior indicator better than conventional clinical factors (AUC\u00a0=\u00a00.732). Furthermore, combining the signature with TNM stage or Fuhrman grade were the optimal indicators (AUC\u00a0=\u00a00.792; AUC\u00a0=\u00a00.800) and processed the clinical applied value for ccRCC. Finally, we found the <jats:italic>SNORA70B<\/jats:italic> and its hose gene <jats:italic>USP34<\/jats:italic> might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC. In general, our study established a six\u2010snoRNA signature as an independent and superior diagnosis and prognosis indicator for ccRCC.<\/jats:p>","DOI":"10.1111\/jcmm.14886","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T09:34:41Z","timestamp":1578994481000},"page":"2215-2228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Expression signature of six\u2010snoRNA serves as novel non\u2010invasive biomarker for diagnosis and prognosis prediction of renal clear cell carcinoma"],"prefix":"10.1111","volume":"24","author":[{"given":"Yanyun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wen","sequence":"additional","affiliation":[{"name":"Urology Department The Second Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Urology Department The Second Hospital of Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzong","family":"Chen","sequence":"additional","affiliation":[{"name":"Bioinformatics and Drug Design Group Department of Pharmacy National University of Singapore Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-7098","authenticated-orcid":false,"given":"Minjie","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy China Medical University Shenyang China"},{"name":"Liaoning Engineering Technology Research Center for the Research, Development and Industrialization of Innovative Peptide Drugs China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3886"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.631"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.05.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-0375"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.09.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18198"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0496"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.02.035"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(98)01260-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/206849"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80263-9"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/383732a0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.11.010"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309359"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-9-198"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0170-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01136"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.070"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.282"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.07.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.9791"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050968"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00008.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22463"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.179"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.4809"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21411"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2760"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elv017"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1186366"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.07.028"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1172"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)01402-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00334-4"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081151"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-104"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.016"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-019-0211-5"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007147"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3563"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.19353"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317711314"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3452"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.06.020"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.14886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.14886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.14886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:26:44Z","timestamp":1694071604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.14886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,14]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jcmm.14886"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.14886","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,14]]},"assertion":[{"value":"2019-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}