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Propionate, one of short\u2010chain fatty acids, exerts cardioprotective effects via reducing blood pressure. This study examined whether prenatal hypoxia impaired propionate\u2010stimulated large\u2010conductance Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010activated K\n                    <jats:sup>+<\/jats:sup>\n                    (BK) channel activities in vascular smooth muscle cells (VSMCs) of offspring. Pregnant rats were exposed to hypoxia (10.5% oxygen) and normoxia (21% oxygen) from gestational day 7\u201021. At 6\u00a0weeks of age, VSMCs in mesenteric arteries of offspring were analysed for BK channel functions and gene expressions. It was shown firstly that propionate could open significantly BK single channel in VSMCs in a concentration\u2010dependent manner. Antagonists of G protein \u03b2\u03b3 subunits and inositol trisphosphate receptor could completely suppress the activation of BK by propionate, respectively. G\u03b1\n                    <jats:sub>i\/o<\/jats:sub>\n                    and ryanodine receptor were found to participate in the stimulation on BK. Compared to the control, vasodilation and increments of BK NPo (the open probability) evoked by propionate were weakened in the offspring by prenatal hypoxia with down\u2010regulated G\u03b2\u03b3 and PLC\u03b2. It was indicated that prenatal hypoxia inhibited propionate\u2010stimulated BK activities in mesenteric VSMCs of offspring via reducing expressions of G\u03b2\u03b3 and PLC\u03b2, in which endoplasmic reticulum calcium release might be involved.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.14994","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T03:30:44Z","timestamp":1579836644000},"page":"3192-3202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal hypoxia inhibited propionate\u2010evoked BK channels of mesenteric artery smooth muscle cells in offspring"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-7399","authenticated-orcid":false,"given":"Wenna","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute for Fetology First Hospital of Soochow University Suzhou 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