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The formation of foam cell plays a key role in the pathogenesis of atherosclerosis. OxLDL is a significant factor in progression of coronary artery disease. Our studies have demonstrated that USP14 promotes cancer development and mediates progression of cardiac hypertrophy and LPS\u2010induced inflammation. However, the underlying mechanism of USP14 is unknown. In this study, we found that the inhibition of USP14 significantly suppressed the oxLDL uptake, subsequently decreased the foam cell formation. Surprisingly, USP14 has an effect on the expression of CD36 but not SR\u2010A, ABCA1, Lox\u20101, ABCG1 and SR\u2010Bl. Furthermore, USP14 stabilizes CD36 protein via cleaving the ubiquitin chain on CD36. Blocking CD36 activation using antibody\u2010dependent blocking assay remarkably attenuated the function of USP14 on the formation of foam cell. In summary, our results suggested that the inhibition of USP14 decreases foam cell formation by down\u2010regulating CD36\u2010mediated lipid uptake and provides a potential therapeutic target for atherosclerosis.<\/jats:p>","DOI":"10.1111\/jcmm.15002","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T04:20:49Z","timestamp":1579753249000},"page":"3292-3302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation"],"prefix":"10.1111","volume":"24","author":[{"given":"Fangcheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangzhou Institute of Cardiovascular Disease Guangdong Key Laboratory of Vascular Diseases State Key Laboratory of Respiratory Disease the Second Affiliated Hospital Guangzhou Medical University Guangzhou 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