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Suppressing the differentiation and resorptive function of osteoclast is a key strategy for treating osteolytic diseases. Dracorhodin perchlorate (D.P), an active component from dragon blood resin, has been used for facilitating wound healing and anti\u2010cancer treatments. In this study, we determined the effect of D.P on osteoclast differentiation and function. We have found that D.P inhibited RANKL\u2010induced osteoclast formation and resorbed pits of hydroxyapatite\u2010coated plate in a dose\u2010dependent manner. D.P also disrupted the formation of intact actin\u2010rich podosome structures in mature osteoclasts and inhibited osteoclast\u2010specific gene and protein expressions. Further, D.P was able to suppress RANKL\u2010activated JNK, NF\u2010\u03baB and Ca<jats:sup>2+<\/jats:sup> signalling pathways and reduces the expression level of NFATc1 as well as the nucleus translocation of NFATc1. Overall, these results indicated a potential therapeutic effect of D.P on osteoclast\u2010related conditions.<\/jats:p>","DOI":"10.1111\/jcmm.15003","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T02:14:32Z","timestamp":1579659272000},"page":"3303-3313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Dracorhodin perchlorate inhibits osteoclastogenesis through repressing RANKL\u2010stimulated NFATc1 activity"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-6677","authenticated-orcid":false,"given":"Yuhao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Joint Orthopaedic The First Affiliated Hospital Guangzhou University of Chinese Medicine Guangzhou China"},{"name":"School of Biomedical Sciences University of Western Australia Perth WA Australia"},{"name":"The Lab of Orthopaedics of Chinese Medicine Lingnan 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