{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:11Z","timestamp":1787015471782,"version":"build-2736575974"},"reference-count":203,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670472"],"award-info":[{"award-number":["81670472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700502"],"award-info":[{"award-number":["81700502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800538"],"award-info":[{"award-number":["81800538"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPAR\u03b3 plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPAR\u03b3\u2010activating potential of natural products. In this manuscript, we will review the research progress of PPAR\u03b3 agonists from natural products in recent years and probe into the application potential and prospects of PPAR\u03b3 natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non\u2010alcoholic fatty liver and liver cancer.<\/jats:p>","DOI":"10.1111\/jcmm.15028","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T06:26:01Z","timestamp":1581056761000},"page":"2736-2748","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Therapeutic potential of PPAR\u03b3 natural agonists in liver diseases"],"prefix":"10.1111","volume":"24","author":[{"given":"Liwei","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Putuo People\u2019s Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Gastroenterology Shanghai Tenth People\u2019s Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-4673","authenticated-orcid":false,"given":"Chuanyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Putuo People\u2019s Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Gastroenterology Shanghai Tenth People\u2019s Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Putuo People\u2019s Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.11.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200522"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/818530"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.02.043"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041212"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00261C"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0118-034R"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.01.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.12.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.02.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X36440"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.01.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5879090"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113540"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0252-4"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27196"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.08.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.04.014"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.04.013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1457"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.104"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202716"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1239-5"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/124624"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.985206"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00037"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.07.018"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2012.05.005"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-010-9398-5"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000194"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2017.03.008"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2007.00606.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2017.12.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102431"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118790"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000428"},{"key":"e_1_2_9_39_1","first-page":"488","article-title":"Identification of PPARgamma agonists from natural sources using different in silico approaches","volume":"81","author":"El\u2010Houri RB","year":"2015","journal-title":"Planta Med"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.03.002"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/20031989819"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.003"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14323"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M900255-JLR200"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981552"},{"key":"e_1_2_9_46_1","first-page":"319","article-title":"Study on activity of dark tea extracts on PPARs model","volume":"28","author":"Song LB","year":"2008","journal-title":"J Tea Sci"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02390-6"},{"key":"e_1_2_9_48_1","first-page":"666","article-title":"Pseudolaric acid analogs as a new class of peroxisome proliferator\u2010activated receptor agonists","volume":"68","author":"Maisa S","year":"2002","journal-title":"Planta Med"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.043"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13497"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/325183"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2388"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.109"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9724217"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3240713"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14543"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28479"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.016"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.323"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.005"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/626319"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01559-5"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/549691"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/215631"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.08.006"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.06.017"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.09.015"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.04.008"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.02.024"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00846"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1046-x"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00450.2005"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00200.2006"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.02.051"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf402082g"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b04805"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.46.30131"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/209520"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/945275"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24024"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3037"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2793"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20994"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i8.1683"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.4.563"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1821"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50186"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2168"},{"key":"e_1_2_9_89_1","first-page":"5417","article-title":"Avicularin ameliorates human hepatocellular carcinoma via the regulation of NFkappaB\/COX2\/PPARgamma activities","volume":"19","author":"Wang Z","year":"2019","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.014"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.6b00766"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.141"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.05.004"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.04.007"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20112704"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/912351"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13190"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050622"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802530861"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.1.5808"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1244"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2006.00220.x"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00342.2011"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118703"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-173716"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126010"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300043200"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1238"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.11.016"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071002"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3912-9"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081878"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.11.003"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/129173"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.01.019"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787909578"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707542"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.04.009"},{"key":"e_1_2_9_119_1","first-page":"5453","article-title":"Synergism from combinations of tris(benzimidazole) monochloroplatinum(II) chloride with capsaicin, quercetin, curcumin and cisplatin in human ovarian cancer cell lines","volume":"34","author":"Arzuman L","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0483873"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149676"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.023"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/23513"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.01.033"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.06.013"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401844"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.04.002"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0377-3"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.08.009"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2015.03.006"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.09.005"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.109"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518765649"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30406-X"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13623"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.12.039"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.076216"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500724"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300386d"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1185386"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5310"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2647129"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.03.021"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.02.001"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf501373a"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.07.005"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3FO60575B"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.011"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.025"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.05.021"},{"key":"e_1_2_9_151_1","first-page":"217","article-title":"Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide\u2010stimulated macrophages by a PPARgamma\u2010dependent pathway","volume":"5","author":"Qiu L","year":"2012","journal-title":"Mol Med Rep"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.11226FP"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.04.007"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-013-9220-4"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.033"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3fo60062a"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-015-0004-7"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.10.006"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.015"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.993038"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.03.015"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.05.033"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9542-2"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111919"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2093-8"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.ess16253"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.150"},{"key":"e_1_2_9_168_1","first-page":"2195","article-title":"Astragalus polysaccharides attenuates TNF\u2010alpha\u2010induced insulin resistance via suppression of miR\u2010721 and activation of PPAR\u2010gamma and PI3K\/AKT in 3T3\u2010L1 adipocytes","volume":"9","author":"Ke B","year":"2017","journal-title":"Am J Transl Res"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2018.02.004"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0357-9"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6079101"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.07.011"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.028"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.10.010"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.05.029"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.04.004"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.1094"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.03.037"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.10.002"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2920-2"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2013.06.021"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1193"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5FO00076A"},{"key":"e_1_2_9_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5413"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19288"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27658"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.03.008"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1089295"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9874-6"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14019"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2016.1255648"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X17500173"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8594767"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11384"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1159\/000494174"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.047"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14437"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108688"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.11.021"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2017.02.002"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900801898656"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.905587"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000125"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2011.06.009"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcmm.15028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15028","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:20:04Z","timestamp":1767176404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":203,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jcmm.15028"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15028","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,7]]},"assertion":[{"value":"2019-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}