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The pathogenesis of depigmentation includes melanocyte dysfunction and loss, which are possibly caused by heredity, autoimmunity and oxidative stress. Among them, oxidative stress plays a key role; however, few clinical treatments can deal with oxidative stress. As reported,\n                    <jats:italic>Cistanche deserticola<\/jats:italic>\n                    polysaccharide (CDP) is an effective antioxidant; based on that, we evaluated its role in melanocyte and further revealed the mechanisms. In this study, we found that CDP could promote melanogenesis in human epidermal melanocytes (HEMs) and mouse melanoma B16F10 cells, it also induced pigmentation in zebrafish. Furthermore, CDP could activate mitogen\u2010activated protein kinase (MAPK) signal pathway, then up\u2010regulated the expression of microphthalmia\u2010associated transcription factor (MITF) and downstream genes\n                    <jats:italic>TYR, TRP1, TRP2<\/jats:italic>\n                    and\n                    <jats:italic>RAB27A<\/jats:italic>\n                    . Otherwise, we found that CDP could attenuate H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced cytotoxicity and apoptosis in melanocytes. Further evidence revealed that CDP could enhance NRF2\/HO\u20101 antioxidant pathway and scavenge intracellular ROS. In summary, CDP can promote melanogenesis and prevent melanocytes from oxidative stress injury, suggesting that CDP helps maintain the normal status of melanocytes. Thus, CDP may be a novel drug for the treatment of depigmentation diseases.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15038","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T10:37:41Z","timestamp":1582627061000},"page":"4023-4035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Cistanche deserticola polysaccharide induces melanogenesis in melanocytes and reduces oxidative stress via activating NRF2\/HO\u20101 pathway"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-0461","authenticated-orcid":false,"given":"Yibo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Dermatology Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Third 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