{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:13Z","timestamp":1787015353784,"version":"build-2736575974"},"reference-count":84,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 815\/Z1"],"award-info":[{"award-number":["SFB 815\/Z1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1213"],"award-info":[{"award-number":["SFB1213"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_U105663142"],"award-info":[{"award-number":["MC_U105663142"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00015\/5"],"award-info":[{"award-number":["MC_UU_00015\/5"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cardiac ischaemia\u2010reperfusion (I\/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Hence, AOX represents a natural rescue mechanism from respiratory stress. This study aimed to determine how respiratory restoration through xenotopically expressed AOX affects the re\u2010perfused post\u2010ischaemic mouse heart. As expected, AOX supports ETC function and attenuates the ROS load in post\u2010anoxic heart mitochondria. However, post\u2010ischaemic cardiac remodelling over 3 and 9\u00a0weeks was not improved. AOX blunted transcript levels of factors known to be up\u2010regulated upon I\/R such as the\n                    <jats:italic>atrial natriuretic peptide<\/jats:italic>\n                    (\n                    <jats:italic>Anp<\/jats:italic>\n                    ) whilst expression of pro\u2010fibrotic and pro\u2010apoptotic transcripts were increased. Ex vivo analysis revealed contractile failure at nine but not 3\u00a0weeks after ischaemia whilst label\u2010free quantitative proteomics identified an increase in proteins promoting adverse extracellular matrix remodelling. Together, this indicates an essential role for ETC\u2010derived signals during cardiac adaptive remodelling and identified ROS as a possible effector.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15043","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T08:32:04Z","timestamp":1581323524000},"page":"3534-3548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-160X","authenticated-orcid":false,"given":"Marten","family":"Szibor","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Institute of Biotechnology University of Helsinki Helsinki Finland"},{"name":"Department of Cardiothoracic Surgery Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Schreckenberg","sequence":"additional","affiliation":[{"name":"Department of Physiology Justus\u2010Liebig University Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-4471","authenticated-orcid":false,"given":"Zemfira","family":"Gizatullina","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-5329","authenticated-orcid":false,"given":"Eric","family":"Dufour","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Wiesnet","sequence":"additional","affiliation":[{"name":"Department Cardiac Development and Remodelling Max Planck Institute for Heart and Lung Research Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-4355","authenticated-orcid":false,"given":"Praveen K.","family":"Dhandapani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Institute of Biotechnology University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-9821","authenticated-orcid":false,"given":"Grazyna","family":"Debska\u2010Vielhaber","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-2849","authenticated-orcid":false,"given":"Juliana","family":"Heidler","sequence":"additional","affiliation":[{"name":"Functional Proteomics Faculty of Medicine Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-8054","authenticated-orcid":false,"given":"Ilka","family":"Wittig","sequence":"additional","affiliation":[{"name":"Functional Proteomics Faculty of Medicine Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-5886","authenticated-orcid":false,"given":"Tuula A.","family":"Nyman","sequence":"additional","affiliation":[{"name":"Department of Immunology Institute of Clinical Medicine Oslo University Hospital University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology Justus\u2010Liebig\u2010University Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Hall","sequence":"additional","affiliation":[{"name":"Medical Research Council Mitochondrial Biology Unit University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Pell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-0566","authenticated-orcid":false,"given":"Carlo","family":"Viscomi","sequence":"additional","affiliation":[{"name":"Medical Research Council Mitochondrial Biology Unit University of Cambridge Cambridge UK"},{"name":"Department of Biomedical Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5192-580X","authenticated-orcid":false,"given":"Thomas","family":"Krieg","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Medical Research Council Mitochondrial Biology Unit University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Braun","sequence":"additional","affiliation":[{"name":"Department Cardiac Development and Remodelling Max Planck Institute for Heart and Lung Research Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-4555","authenticated-orcid":false,"given":"Frank N.","family":"Gellerich","sequence":"additional","affiliation":[{"name":"Department of Neurology Otto\u2010von\u2010Guericke\u2010University Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-4919","authenticated-orcid":false,"given":"Klaus\u2010Dieter","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"Department of Physiology Justus\u2010Liebig University Giessen Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1895-6003","authenticated-orcid":false,"given":"Howard T.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University Tampere Finland"},{"name":"Institute of Biotechnology University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.55.2.168"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46660-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31821b1a92"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c15-00693"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01745863"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(89)90431-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90577-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2015.00029"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.20151332T1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0513"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715769800300271"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.01.034"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3718com"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.05.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1892"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.044"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002206"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.10.039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.009"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13909"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.020"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2006.08.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042811-105432"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400601"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900001"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.03.004"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003182"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.027839"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2018-0261OC"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2019.148137"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003647"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809456"},{"key":"e_1_2_9_40_1","first-page":"101","article-title":"Myocarditis induced by targeted expression of the MCP\u20101 gene in murine cardiac muscle","volume":"152","author":"Kolattukudy PE","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49231-9"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp555"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0696-8"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.12.002"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.03.009"},{"key":"e_1_2_9_46_1","first-page":"e116","article-title":"Impaired oxidative phosphorylation in overtrained rat myocardium","volume":"15","author":"Kadaja L","year":"2010","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.61"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00307-3"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1511"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw936"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-383-1_9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.6.5.656"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0374"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2018_143"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.04.053"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140973.60992.9A"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.012"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp092"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz049"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361603"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912457"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.09.021"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-48"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030039"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0358-9"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.07.244"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248413515750"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016288"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.07.001"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119770"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1139\/y11-040"},{"key":"e_1_2_9_74_1","first-page":"189","article-title":"Analytical issues with natriuretic peptides\u2014has this been overly simplified?","volume":"27","author":"Semenov AG","year":"2016","journal-title":"Ejifcc"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2004.028"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.5.H1500"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00704.2012"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000074905.22908.A6"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00468.2006"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000161873.27088.4c"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1619"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010062"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2013.09.013"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42028"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018090-00009"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.15043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.15043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:01:11Z","timestamp":1694008871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.15043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":84,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jcmm.15043"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.15043","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]},"assertion":[{"value":"2019-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}