{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:13:27Z","timestamp":1790964807183,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Municipal Education Commission Science and Technology Plan General Project","award":["KM201910025010"],"award-info":[{"award-number":["KM201910025010"]}]},{"name":"With The Special Fund of The Pediatric Medical Coordinated Development Center of Beijing Municipal Administration","award":["No: XTYB201819"],"award-info":[{"award-number":["No: XTYB201819"]}]},{"name":"Research on the application of clinical characteristics of the Beijing Municipal Science and Technology Commission","award":["Z171100001017048"],"award-info":[{"award-number":["Z171100001017048"]}]},{"name":"Beijing Children\u2019s Hospital Affiliated to Capital Medical University, National Natural Science Foundation of China","award":["GPMS201903"],"award-info":[{"award-number":["GPMS201903"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiac hypertrophy (CH) is a common cardiac disease and is closely associated with heart failure. Protocadherin 17 (PCDH17) was reported to aggravate myocardial infarction. Present study was designed to illustrate the impact of PCDH17 and the mechanism of PCDH17 expression regulation in CH. CH model in vivo and in vitro was established by transverse aortic constriction (TAC) and Ang\u2010II treatment. Hypertrophy was evaluated in PMC and H9c2 cells by examining cell surface area and hypertrophic markers. Results demonstrated that PCDH17 was up\u2010regulated in CH in vivo and in vitro. PCDH17 knock\u2010down alleviated hypertrophic response in Ang\u2010II\u2010induced cardiomyocytes. By means of ENCORI database and a series of mechanism assays, miR\u2010322\u20105p and miR\u2010384\u20105p were identified to interact with and inhibit PCDH17. Next, lncRNA SNHG14 (small nucleolar RNA host gene 14) was validated to sponge both miR\u2010322\u20105p and miR\u2010384\u20105p to elevate PCDH17 level. The subsequent rescue assays revealed that miR\u2010322\u20105p and miR\u2010384\u20105p restored SNHG14 depletion\u2010mediated suppression on hypertrophy in Ang\u2010II\u2010induced cardiomyocytes. Besides, Sp1 transcription factor (SP1) was verified as the transcription factor activating both SNHG14 and PCDH17. Both SNHG14 and PCDH17 reversed SP1 knock\u2010down\u2010mediated repression on hypertrophy in Ang\u2010II\u2010induced cardiomyocytes. Together, present study first uncovered ceRNA network of SNHG14\/miR\u2010322\u20105p\/miR\u2010384\u20105p\/PCDH17 in Ang\u2010II\u2010induced cardiomyocytes.<\/jats:p>","DOI":"10.1111\/jcmm.15073","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T06:40:30Z","timestamp":1590043230000},"page":"7115-7126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["SP1\u2010induced SNHG14 aggravates hypertrophic response in in vitro model of cardiac hypertrophy via up\u2010regulation of PCDH17"],"prefix":"10.1111","volume":"24","author":[{"given":"Yadong","family":"Long","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-8359","authenticated-orcid":false,"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery II National Center for Children\u2019s Health Beijing Children\u2019s Hospital Capital Medical University Beijing 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