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We hypothesize that SARI may also play a role in ocular diseases involving inflammation and neovascularization. To explore our hypothesis, further, we investigated an\u00a0endotoxin\u2010induced\u00a0uveitis\u00a0(EIU) and experimental argon laser\u2010induced\u00a0choroidal\u00a0neovascularization (CNV) model in SARI wild\u2010type (SARI\n                    <jats:sup>WT<\/jats:sup>\n                    ) and SARI\u2010deficient (SARI\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice. Through imaging, morphological and\u00a0immunohistochemical (IHC) studies, we found\u00a0that SARI deficiency\u00a0exacerbated the growth of CNV. More VEGF\u2010positive cells were presented in the\u00a0retina\u00a0of SARI\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice with CNV. Compared to SARI\n                    <jats:sup>WT<\/jats:sup>\n                    \u00a0mice, more\u00a0inflammatory cells infiltrated the ocular anterior segment and posterior segments in SARI\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice with EIU. Collectively, the results point to a potential dual functional role of SARI in inflammatory\u00a0ocular diseases, suggesting that SARI could be a potential therapy target for\u00a0ocular inflammation and\u00a0neovascularization.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15096","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T13:12:49Z","timestamp":1583154769000},"page":"4341-4349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["SARI prevents ocular angiogenesis and inflammation in mice"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-1425","authenticated-orcid":false,"given":"Wenqiu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology West China Hospital Sichuan University Chengdu China"},{"name":"Research Laboratory of Ophthalmology and Vision Sciences West China Hospital Sichuan University Chengdu China"},{"name":"Department of Optometry and Visual Science West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-3043","authenticated-orcid":false,"given":"Lei","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology West China Hospital Sichuan University Chengdu China"},{"name":"Research Laboratory of Ophthalmology and Vision Sciences West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation 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