{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:36:15Z","timestamp":1789598175114,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81872200"],"award-info":[{"award-number":["81872200"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["31900558"],"award-info":[{"award-number":["31900558"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2018CFB510"],"award-info":[{"award-number":["2018CFB510"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammation indicators, such as systemic inflammation response index (SIRI), systemic immune\u2010inflammation index (SII), neutrophil\u2010to\u2010lymphocyte ratio (NLR) and platelet\u2010lymphocyte ratio (PLR), are associated with poor prognosis in various solid cancers. In this study, we investigated the predictive value of these inflammation indicators in nasopharyngeal carcinoma (NPC). This retrospective study involved 559 patients with NPC and 500 patients with chronic rhinitis, and 255 NPC patients were followed up successfully. Continuous variables and qualitative variables were measured by t test and chi\u2010square test, respectively. The optimal cut\u2010off values of various inflammation indicators were determined by receiver operating characteristic (ROC) curve. Moreover, the diagnostic value for NPC was decided by the area under the curves (AUCs). The Kaplan\u2010Meier methods and the log\u2010rank test were used to analyse overall survival (OS) and disease\u2010free survival (DFS). The independent prognostic risk factors for survival and influencing factors of side effects after treatment were analysed by Cox and logistic regression analysis, respectively. Most haematological indexes of NPC and rhinitis were significantly different between the two groups, and PLR was optimal predictive indicators of diagnosis. In the multivariable Cox regression analysis, PLR, WBC, RDW, M stage and age were independent prognostic risk factors. Many inflammation indicators that affected various side effects were evaluated by logistic regression analysis. In conclusion, the combined inflammation indicators were superior to single haematological indicator in the diagnosis and prognosis of NPC. These inflammation indicators can be used to supply the current evaluation system of the TNM staging system to help predict the prognosis in NPC patients.<\/jats:p>","DOI":"10.1111\/jcmm.15097","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T15:55:54Z","timestamp":1593532554000},"page":"8326-8349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Development and validation of immune inflammation\u2013based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaojiao","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Zhongnan Hospital of Wuhan University Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology Zhongnan 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