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Osthole is a bioactive derivative from\n                    <jats:italic>coumarin<\/jats:italic>\n                    with a wide range of pharmacotherapeutic effects. The aim of this study was to unveil the potential protective role of osthole in alcohol\u2010induced ONFH. In vitro, ethanol (50\u00a0mmol\/L) remarkably decreased the proliferation and osteogenic differentiation of BMSCs and impaired the proliferation and tube formation capacity of human umbilical vein endothelial cell (HUVECs), whereas it substantially promoted the adipogenic differentiation of BMSCs. However, osthole could reverse the effects of ethanol on osteogenesis\n                    <jats:italic>via<\/jats:italic>\n                    modulating Wnt\/\u03b2\u2010catenin pathway, stimulate vasculogenesis and counteract adipogenesis. In vivo, the protective role of osthole was confirmed in the well\u2010constructed rat model of ethanol\u2010induced ONFH, demonstrated by a cascade of radiographical and pathological investigations including micro\u2010CT scanning, haematoxylin\u2010eosin staining, TdT\u2010mediated dUTP nick end labelling, immunohistochemical staining and fluorochrome labelling. Taken together, for the first time, osthole was demonstrated to rescue the ethanol\u2010induced ONFH\n                    <jats:italic>via<\/jats:italic>\n                    promoting bone formation, driving vascularization and retarding adipogenesis.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15103","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T12:55:35Z","timestamp":1583412935000},"page":"4439-4451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol\u2010induced osteonecrosis of the femoral head"],"prefix":"10.1111","volume":"24","author":[{"given":"Hongping","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 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