{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:36:33Z","timestamp":1792445793699,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondation Stargardt \/ RETINA FRANCE","award":["2017-03"],"award-info":[{"award-number":["2017-03"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    All\u2010\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010retinal (a\n                    <jats:italic>t<\/jats:italic>\n                    RAL) is a highly reactive carbonyl specie, known for its reactivity on cellular phosphatidylethanolamine in photoreceptor. It is generated by photoisomerization of 11\u2010\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010retinal chromophore linked to opsin by the Schiff's base reaction. In ABCA4\u2010associated autosomal recessive Stargardt macular dystrophy, a\n                    <jats:italic>t<\/jats:italic>\n                    RAL results in carbonyl and oxidative stress, which leads to bisretinoid A2E, accumulation in the retinal pigment epithelium (RPE). This A2E\u2010accumulation presents as lipofuscin fluorescent pigment, and its photooxidation causes subsequent damage. Here we describe protection against a lethal dose of a\n                    <jats:italic>t<\/jats:italic>\n                    RAL in both photoreceptors and RPE in primary cultures by a lipidic polyphenol derivative, an isopropyl\u2010phloroglucinol linked to DHA, referred to as IP\u2010DHA. Next, we addressed the cellular and molecular defence mechanisms in commonly used human ARPE\u201019 cells. We determined that both polyunsaturated fatty acid and isopropyl substituents bond to phloroglucinol are essential to confer the highest protection. IP\u2010DHA responds rapidly against the toxicity of a\n                    <jats:italic>t<\/jats:italic>\n                    RAL and its protective effect persists. This healthy effect of IP\u2010DHA applies to the mitochondrial respiration. IP\u2010DHA also rescues RPE cells subjected to the toxic effects of A2E after blue light exposure. Together, our findings suggest that the beneficial role of IP\u2010DHA in retinal cells involves both anti\u2010carbonyl and anti\u2010oxidative capacities.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.15135","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T05:42:11Z","timestamp":1585114931000},"page":"5057-5069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Isopropyl\u2010phloroglucinol\u2010DHA protects outer retinal cells against lethal dose of all\u2010\n                    <i>trans<\/i>\n                    \u2010retinal"],"prefix":"10.1111","volume":"24","author":[{"given":"Aur\u00e9lie","family":"Cubizolle","sequence":"first","affiliation":[{"name":"INSERM U1051 Institut des Neurosciences de Montpellier Montpellier France"},{"name":"Universit\u00e9 Montpellier Montpellier 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