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By binding with its receptors, S1P can serve as mediator of signalling during cell migration, differentiation, proliferation and apoptosis. Although the predominant role of S1P in bone regeneration has been noted in many studies, this role is not as well\u2010known as its roles in the cardiovascular and immune systems. In this review, we summarize previous research on the role of S1P receptors (S1PRs) in osteoblasts and osteoclasts. In addition, S1P is regarded as a bridge between bone resorption and formation, which brings hope to patients with bone\u2010related diseases. Finally, we discuss S1P and its receptors as therapeutic targets for treating osteoporosis, inflammatory osteolysis and bone metastasis based on the biological effects of S1P in osteoclastic\/osteoblastic cells, immune cells and tumour cells.<\/jats:p>","DOI":"10.1111\/jcmm.15155","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T20:47:22Z","timestamp":1583873242000},"page":"4389-4401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sphingosine\u20101\u2010phosphate (S1P) receptors: Promising drug targets for treating bone\u2010related diseases"],"prefix":"10.1111","volume":"24","author":[{"given":"Lincheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Materials Science Third Military Medical University (Army Medical University) Chongqing China"},{"name":"Battalion One of Basic Medical Sciences Third Military Medical University (Army 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