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Numerous studies have demonstrated that long non\u2010coding RNA (lncRNA) is involved in various human diseases including cancer. LncRNA FTX was firstly identified in Xist gene locus and was dysregulated in many human cancers. However, the function of FTX in NSCLC is still unclear. Here, we report that long non\u2010coding RNA FTX expression level is down\u2010regulated in NSCLC clinical tissue samples and cell lines. Ectopic expression of FTX inhibits proliferation and metastasis of lung cancer cells in vitro and in vivo. Furthermore, we find that FTX overexpression activates the expression of transcription factor FOXA2, an important regulator in lung cancer progression, and we reveal a novel FTX\/miR\u2010200a\u20103p\/FOXA2 competing endogenous RNA regulatory axis in lung cancer cells. Our results provide new insights and directions for exploring the function of FTX in lung cancer progression.<\/jats:p>","DOI":"10.1111\/jcmm.15163","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T12:55:32Z","timestamp":1584363332000},"page":"4839-4849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["LncRNA FTX activates FOXA2 expression to inhibit non\u2013small\u2010cell lung cancer proliferation and metastasis"],"prefix":"10.1111","volume":"24","author":[{"given":"Shidai","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University Nanjing 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