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Here, we have explored the anti\u2010fibrotic effects of propylene glycol alginate sodium sulphate (PSS), a natural extract from brown algae, in fibrotic mice and cell models. Thus, we established bile duct ligature and carbon tetrachloride mouse models and LX\u20102 cell models with or without PSS treatment. Liver pathological sections and the relevant indicators in serum and liver tissues were examined. PSS prevented hepatic injury and fibrosis to a significant extent, and induced up\u2010regulation of matrix metalloproteinase\u20102 and down\u2010regulation of tissue inhibitor of metalloproteinase\u20101 through suppressing the transforming growth factor \u03b21 (TGF\u2010\u03b21)\/Smad pathway. PSS additionally exerted an anti\u2010autophagy effect through suppressing the Janus kinase (JAK) 2\/transducer and activator of transcription 3 (STAT3) pathway. In conclusion, PSS prevents hepatic fibrosis by suppressing inflammation, promoting extracellular matrix (ECM) decomposition and inactivating hepatic stellate cells through mechanisms involving the TGF\u2010\u03b21\/Smad2\/3 and JAK2\/STAT3 pathways in vivo and in vitro.<\/jats:p>","DOI":"10.1111\/jcmm.15175","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T08:51:34Z","timestamp":1585644694000},"page":"5224-5237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["TGF\u2010\u03b2\/Smad and JAK\/STAT pathways are involved in the anti\u2010fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis"],"prefix":"10.1111","volume":"24","author":[{"given":"Shizan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Putuo People's Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of 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