{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:53:41Z","timestamp":1789678421192,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T00:00:00Z","timestamp":1588204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease, affecting up to 10% to 20% of children and 3% of adults. Although allergen sensitization, skin barrier abnormalities and type 2 immune responses are involved, the exact molecular pathogenesis of AD remains unclear. MicroRNAs (miRNAs) are short (19\u201025 nucleotides) single\u2010stranded RNA molecules that regulate gene expression at post\u2010transcriptional level and are implicated in the pathogenesis of many inflammatory and immunological skin disorders. This systematic review sought to summarize our current understanding regarding the role of miRNAs in AD development. We searched articles indexed in PubMed (MEDLINE) and Web of Science databases using Medical Subject Heading (MeSH) or Title\/Abstract words (\u2018microRNA\/miRNA\u2019 and \u2018atopic dermatitis\/eczema\u2019) from inception through January 2020. Observational studies revealed dysregulation of miRNAs, including miR\u2010143, miR\u2010146a, miR\u2010151a, miR\u2010155 and miR\u2010223, in AD patients. Experimental studies confirmed their functions in regulating keratinocyte proliferation\/apoptosis, cytokine signalling and nuclear factor\u2010\u03baB\u2010dependent inflammatory responses, together with T helper 17 and regulatory T cell activities. Altogether, this systematic review brings together contemporary findings on how deregulation of miRNAs contributes to AD.<\/jats:p>","DOI":"10.1111\/jcmm.15208","type":"journal-article","created":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T07:57:07Z","timestamp":1588233427000},"page":"5966-5972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["MicroRNAs in atopic dermatitis: A systematic review"],"prefix":"10.1111","volume":"24","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Friendship Hospital Capital Medical University Beijing 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Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0061-4913","authenticated-orcid":false,"given":"William Ka Kei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute The Chinese University of Hong Kong Hong Kong Hong Kong"},{"name":"State Key Laboratory of Digestive Diseases and LKS Institute of Health Sciences The Chinese University of Hong Kong Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,30]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"9","article-title":"The epidemiology of atopic dermatitis","volume":"31","author":"Schultz LF","year":"1993","journal-title":"Monogr 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