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They are abnormal proliferations of trophoblast cells that have the potential to become cancerous. miR\u2010miR30a\u20105p is a tumour suppressor that participates in the development of numerous diseases. However, the role of miR\u201030a in hydatidiform moles and the mechanisms underlying its effects are presently unclear. This study explored the levels of miR\u201030a and B3GNT5 expression in human hydatidiform mole tissue. The results showed that miR\u201030a and B3GNT5 were differentially expressed in normal placenta and hydatidiform mole, and miR\u201030a decreased cell proliferation, invasion and migration in trophoblast cell lines. Upon further examination, it was confirmed that miR\u201030a directly targeted the 3\u2019untranslated region of B3GNT5 using a dual\u2010luciferase assay. The results of the present study also revealed that miR\u201030a reduced the proliferation, invasion and migration ability in JAR and BeWo cells by regulating B3GNT5, which may inactivate the ERK and AKT signalling pathways. This study demonstrated that miR\u201030a was a novel target B3GNT5 that serves an important role in the development of hydatidiform moles, suggesting that miR\u201030a may serve as a novel potential biomarker or useful diagnostic and therapeutic tool for hydatidiform moles in clinical settings.<\/jats:p>","DOI":"10.1111\/jcmm.15247","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T23:48:41Z","timestamp":1592956121000},"page":"8350-8362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["MiR\u201030a\u20105p inhibits proliferation and metastasis of hydatidiform mole by regulating B3GNT5 through ERK\/AKT pathways"],"prefix":"10.1111","volume":"24","author":[{"given":"Zhenzhen","family":"Guo","sequence":"first","affiliation":[{"name":"Core Lab Glycobiol &amp; Glycoengn College of Basic Medical Sciences Dalian Medical University Dalian 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