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However, the complicate processes of its development and involution are incompletely understood. Accumulating evidence indicates that non\u2010coding RNAs play key roles in the regulation of biological development. At present, the studies of the circRNA profiles and of circRNA\u2010associated competing endogenous RNAs (ceRNAs) in the thymus are still scarce. Here, deep\u2010RNA sequencing was used to study the biological mechanisms underlying the development process (from 2\u2010week\u2010old to 6\u2010week\u2010old) and the recession process (from 6\u2010week\u2010old to 3\u2010month\u2010old) of the mouse thymus. It was found that 196 circRNAs, 233 miRNAs and 3807 mRNAs were significantly dysregulated. The circRNA\u2010associated ceRNA networks were constructed in the mouse thymus, which were mainly involved in early embryonic development and the proliferation and division of T cells. Taken together, these results elucidated the regulatory roles of ceRNAs in the development and involution processes of the mouse thymus.<\/jats:p>","DOI":"10.1111\/jcmm.15276","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:59:52Z","timestamp":1587344392000},"page":"6340-6349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comprehensive analysis of circRNA expression profiles and circRNA\u2010associated competing endogenous RNA networks in the development of mouse thymus"],"prefix":"10.1111","volume":"24","author":[{"given":"Wenting","family":"Li","sequence":"first","affiliation":[{"name":"Biomedical Research Institute Shenzhen Peking University \u2010 The Hong Kong University of Science and Technology Medical Center Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Ma","sequence":"additional","affiliation":[{"name":"Biomedical 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