{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:17:14Z","timestamp":1778919434393,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2014CFC1026"],"award-info":[{"award-number":["2014CFC1026"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>LIVIN, a member of the inhibitor of apoptosis proteins (IAPs), is reported playing important roles in the development and progression of multiple human cancers. However, its underlined mechanisms in human renal cell carcinoma (RCC) are still needed to be clarified. In the present study, we reported that inhibition of miR\u2010214 promoted the expression of LIVIN, then facilitated RCC cells growth and reduced the sensitivity of RCC cells to chemotherapeutic drugs. In constant, overexpression of miR\u2010214 had contradictory effects. Further investigation showed that miR\u2010214 was down\u2010regulated in RCC because of abnormal methylation. In addition, DNA methyltransferase DNMT1, miR\u2010214 and LIVIN are directly correlated in RCC patients. In conclusion, these results suggest that abnormal miR\u2010214 methylation negatively regulates LIVIN, which may promote RCC cells growth and reduced the sensitivity of RCC cells to chemotherapeutic drugs.<\/jats:p>","DOI":"10.1111\/jcmm.15287","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T13:36:07Z","timestamp":1589290567000},"page":"6410-6425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["RETRACTED: Methylation\u2010mediated miR\u2010214 regulates proliferation and drug sensitivity of renal cell carcinoma cells through targeting LIVIN"],"prefix":"10.1111","volume":"24","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Urology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Abdominal and Pelvic Medical Oncology II Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Shi","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Centre of Drum Tower Hospital Medical School of Nanjing University &amp; 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