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The aim of this study was to investigate the regulating role of LINC00261 in hypoxia\/reoxygenation (H\/R)\u2010induced cardiomyocyte apoptosis. The relative expression of LINC00261, miR\u201023b\u20103p and NRF2 were determined in rats I\/R myocardial tissues and H\/R\u2010induced cardiomyocytes. The rat model and cell model of LINC00261 overexpression were established to investigate the biological function of LINC00261 on H9C2 cell. The interaction between LINC00261, miR\u201023b\u20103p, NRF2 and FOXO3a was identified using bioinformatics analysis, luciferase reporter assay, RNA immunoprecipitation (RIP) assay, chromatin immunoprecipitation (CHIP) assay and qRT\u2010PCR. The expression of LINC00261 was significantly down\u2010regulated in myocardial tissues and H9C2 cell. Overexpression of LINC00261 improves cardiac function and reduces myocardium apoptosis. Interestingly, transcription factor FOXO3a was found to promote LINC00261 transcription. Moreover, LINC00261 was confirmed as a spong of miR23b\u20103p and thereby positively regulates NRF2 expression in cardiomyocytes. Our findings reveal a novel role for LINC00261 in regulating H\/R cardiomyocyte apoptosis and the potency of the LINC00261\/miR\u201023b\u20103p\/NRF2 axis as a therapeutic target for the treatment of MIRI.<\/jats:p>","DOI":"10.1111\/jcmm.15292","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T23:54:01Z","timestamp":1592524441000},"page":"8368-8378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["FOXO3a\u2010mediated long non\u2010coding RNA LINC00261 resists cardiomyocyte hypoxia\/reoxygenation injury via targeting miR23b\u20103p\/NRF2 axis"],"prefix":"10.1111","volume":"24","author":[{"given":"Ruining","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Hospital of Hebei Medical University  Shijiazhuang HeBei China"},{"name":"The Hebei Institute of Cardiovascular and Cerebrovascular Diseases (YL) Shijiazhuang 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